IL13RA1 and TRAF3IP1

Number of citations of the paper that reports this interaction (PubMedID 12935900)
0

Data Source:
HPRD (two hybrid, in vivo)

		IL13RA1	TRAF3IP1
Description		interleukin 13 receptor subunit alpha 1	TRAF3 interacting protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Membrane Receptor Complex	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Protein Binding Microtubule Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		Interleukin-4 and Interleukin-13 signaling	Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Body mass index ( 28892062) Type 2 diabetes ( 30718926)	Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		7 interacting genes: DLG4 IL13 IL4R TMEM132D TMEM39B TRAF3IP1 TYK2	31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC
Entrez ID		3597	26146
HPRD ID		02125	09571
Ensembl ID		ENSG00000131724	ENSG00000204104
Uniprot IDs		P78552	Q8TDR0
PDB IDs		3BPN 3BPO 4HWB 5E4E	2EQO 8KCQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Degranulation P2Y1 Nucleotide Receptor Binding Positive Regulation Of Lymphocyte Activation Regulation Of Cytokine Production Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Immunoglobulin Production Regulation Of Macrophage Activation Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-13 Receptor Binding Negative Regulation Of Lung Ciliated Cell Differentiation Cytokine-mediated Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of Exocytosis Response To Other Organism Positive Regulation Of Cold-induced Thermogenesis Interleukin-4 Receptor Activity Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Regulation Of Vesicle-mediated Transport Response To External Biotic Stimulus Regulation Of Alpha-beta T Cell Activation Regulation Of Regulated Secretory Pathway Interleukin-13-mediated Signaling Pathway Interleukin-12 Receptor Complex Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Interleukin-23 Receptor Complex AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Leukocyte Proliferation Transforming Growth Factor Beta1 Production Regulation Of Multicellular Organismal Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Exocytosis Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation Morphogenesis Of A Polarized Epithelium D1 Dopamine Receptor Binding Regulation Of Production Of Molecular Mediator Of Immune Response	Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation
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