IL11 and S100P

Number of citations of the paper that reports this interaction (PubMedID 34933172)
0

Data Source:
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		IL11	S100P
Description		interleukin 11	S100 calcium binding protein P
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-11 Receptor Binding Protein Binding Growth Factor Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Cell Population Proliferation Positive Regulation Of Cell Population Proliferation B Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process	Endothelial Cell Migration
Pathways		IL-6-type cytokine receptor ligand interactions	Neutrophil degranulation
Drugs			Cromoglicic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Osteoarthritis (hip) ( 30374069) Response to antidepressants ( 20360315)	Obesity-related traits ( 23251661)
Interacting Genes		7 interacting genes: IL11RA MAGEA11 S100A1 S100A6 S100B S100P UBQLN2	46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A
Entrez ID		3589	6286
HPRD ID		00980	02792
Ensembl ID		ENSG00000095752	ENSG00000163993
Uniprot IDs		A8K3F7 P20809	P25815
PDB IDs		4MHL 6O4O 8DPS 8DPT 8DPU 8DPV 8DPW 8QY4	1J55 1OZO 2MJW 7NMI
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Calcium Ion Binding Protein Homodimerization Activity Identical Protein Binding Extracellular Region Ruffle Negative Regulation Of G Protein-coupled Receptor Internalization Interleukin-11 Receptor Activity Interleukin-11 Binding Axonogenesis Negative Regulation Of Clathrin-dependent Endocytosis Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Interleukin-11-mediated Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation
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