IL11 and IL11RA

Number of citations: 0 (PubMedID 7670098)
Data Source: HPRD (in vivo, in vitro)

		IL11	IL11RA
Name		interleukin 11	interleukin 11 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-11 Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Interleukin-11 Binding
	Biological Process	Cell Population Proliferation Positive Regulation Of Cell Population Proliferation B Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process	Embryo Implantation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs		None	Oprelvekin
GWAS		Appendicular lean mass ( 33097823 ) Osteoarthritis (hip) ( 30374069 ) Response to antidepressants ( 20360315 )	CTACK levels ( 27989323 )
Novel Interactors		None recorded	2 novel interactors: CCL21 ELAVL2
Interacting Genes		7 interacting genes: IL11RA MAGEA11 S100A1 S100A6 S100B S100P UBQLN2	3 interacting genes: IL11 OLFM4 USP40
Entrez ID		3589	3590
HPRD ID		00980	02965
Ensembl ID		ENSG00000095752	ENSG00000137070
Uniprot IDs		A8K3F7 P20809	Q14626
PDB IDs		4MHL 6O4O 8DPS 8DPT 8DPU 8DPV 8DPW 8QY4	6O4P 8DPS 8DPT 8DPU 8QY4
GO Terms Enriched among Interactors		Calcium-dependent Protein Binding S100 Protein Binding Calcium Ion Binding Protein Homodimerization Activity Identical Protein Binding Extracellular Region Ruffle Negative Regulation Of G Protein-coupled Receptor Internalization Interleukin-11 Receptor Activity Interleukin-11 Binding Axonogenesis Negative Regulation Of Clathrin-dependent Endocytosis Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Interleukin-11-mediated Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation	Interleukin-11 Receptor Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cytokine Activity Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Cell-substrate Adhesion Interleukin-11-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Complement-dependent Cytotoxicity Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Immunological Synapse Formation Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of Canonical NF-kappaB Signal Transduction Chemokine Receptor Binding Establishment Of T Cell Polarity Negative Regulation Of Cellular Extravasation Azurophil Granule Specific Granule Regulation Of Leukocyte Tethering Or Rolling Regulation Of T Cell Chemotaxis Cellular Response To Chemokine Dendritic Cell Chemotaxis Cytokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Lymphocyte Chemotaxis