IL11

Name	interleukin 11
Structure
Interactors	7 interactors: IL11RA MAGEA11 S100A1 S100A6 S100B S100P UBQLN2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-11 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Population Proliferation Positive Regulation Of Cell Population Proliferation B Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways	IL-6-type cytokine receptor ligand interactions
GWAS	Appendicular lean mass ( 33097823 ) Osteoarthritis (hip) ( 30374069 ) Response to antidepressants ( 20360315 )
Entrez ID	3589
HPRD ID	00980
Ensembl ID	ENSG00000095752
Uniprot IDs	A8K3F7 P20809
PDB IDs	4MHL 6O4O 8DPS 8DPT 8DPU 8DPV 8DPW 8QY4
GO Terms Enriched among Interactors ?	Calcium-dependent Protein Binding S100 Protein Binding Calcium Ion Binding Protein Homodimerization Activity Identical Protein Binding Extracellular Region Ruffle Negative Regulation Of G Protein-coupled Receptor Internalization Interleukin-11 Receptor Activity Interleukin-11 Binding Axonogenesis Negative Regulation Of Clathrin-dependent Endocytosis Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Interleukin-11-mediated Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation