IL11

Description		interleukin 11
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-11 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Population Proliferation Positive Regulation Of Cell Population Proliferation B Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Osteoarthritis (hip) ( 30374069) Response to antidepressants ( 20360315)
Interacting Genes		7 interacting genes: IL11RA MAGEA11 S100A1 S100A6 S100B S100P UBQLN2
Entrez ID		3589
HPRD ID		00980
Ensembl ID		ENSG00000095752
Uniprot IDs		A8K3F7 P20809
PDB IDs		4MHL 6O4O 8DPS 8DPT 8DPU 8DPV 8DPW 8QY4
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding S100 Protein Binding Calcium Ion Binding Protein Homodimerization Activity Identical Protein Binding Extracellular Region Ruffle Negative Regulation Of G Protein-coupled Receptor Internalization Interleukin-11 Receptor Activity Interleukin-11 Binding Axonogenesis Negative Regulation Of Clathrin-dependent Endocytosis Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Interleukin-11-mediated Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation
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