DHX36 and MIR222

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		DHX36	MIR222
Description		DEAH-box helicase 36	microRNA 222
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Cell Projection Perikaryon Extracellular Exosome	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity MRNA 3'-UTR AU-rich Region Binding Histone Deacetylase Binding Metal Ion Binding MRNA 5'-UTR Binding G-quadruplex DNA Binding Telomerase RNA Binding Pre-miRNA Binding Catalytic Activity, Acting On A Nucleic Acid	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Ossification Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of Transcription By RNA Polymerase III Regulation Of Translation Spermatogenesis Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Translation Cell Differentiation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Telomere Maintenance Positive Regulation Of Interferon-alpha Production Cellular Response To Heat Cellular Response To UV Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Regulation Of MRNA Stability Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Defense Response To Virus Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Dendritic Spine Morphogenesis 3'-UTR-mediated MRNA Destabilization Telomerase RNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Arsenite Ion Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Cytoplasmic Translation	Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Negative Regulation Of Interleukin-21 Production MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Axon Regeneration Negative Regulation Of Inflammatory Response Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Schwann Cell Migration Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Drugs
Diseases
GWAS		Body mass index ( 29273807) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		72 interacting genes: DUX4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I RNF10 TLR1 ZFP36	75 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LIN28A LRPPRC MATR3 MSI2 NONO PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RBFOX2 RBM14 RBM4 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		170506	407007
HPRD ID		09918
Ensembl ID		ENSG00000174953	ENSG00000207725
Uniprot IDs		Q9H2U1
PDB IDs		2N16 2N21 6Q6R
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Extracellular Space Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis	RNA Binding Nucleic Acid Binding RNA Processing RNA Splicing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Macromolecule Metabolic Process Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Catalytic Step 2 Spliceosome Nucleoplasm Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding MiRNA Binding Regulation Of Gene Expression Cytoplasmic Stress Granule Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Gene Expression Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex CRD-mediated MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-UTR Binding Regulation Of MRNA Stability Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Translation
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