DHX36

Gene Name		DEAH (Asp-Glu-Ala-His) box polypeptide 36
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding G-quadruplex RNA Binding Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding G-quadruplex DNA Binding
	Biological Process	Ossification Transcription, DNA-templated RNA Processing Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade Cytosolic sensors of pathogen-associated DNA MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: IL7R TLR1 ZFP36
Entrez ID		170506
HPRD ID		09918
Ensembl ID		ENSG00000174953
Uniprot IDs		Q9H2U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Regulation Of Immune System Process Interleukin-7-mediated Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Immune System Process Detection Of Bacterial Lipoprotein Negative Regulation Of Translation Involved In Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Leukocyte Activation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide RNA Destabilization Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lymph Node Development Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Interleukin-6 Biosynthetic Process Cell Activation Detection Of Bacterium Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Detection Of Biotic Stimulus Macrophage Activation Regulation Of Immune Response Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immune System Process Gene Silencing By MiRNA Negative Regulation Of Adaptive Immune Response Posttranscriptional Gene Silencing B Cell Proliferation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Stability Immunoglobulin Production Gene Silencing By RNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses