DHX36 and TLR1

Number of citations of the paper that reports this interaction (PMID 16482509)
13

Data Source:
HPRD (two hybrid)

		DHX36	TLR1
Gene Name		DEAH (Asp-Glu-Ala-His) box polypeptide 36	toll-like receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
	Molecular Function	Core Promoter Binding G-quadruplex RNA Binding Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding G-quadruplex DNA Binding	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Ossification Transcription, DNA-templated RNA Processing Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade Cytosolic sensors of pathogen-associated DNA MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS			Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		3 interactors: IL7R TLR1 ZFP36	9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1
Entrez ID		170506	7096
HPRD ID		09918	03119
Ensembl ID		ENSG00000174953	ENSG00000174125
Uniprot IDs		Q9H2U1	Q15399 Q32MK4
PDB IDs			1FYV 2Z7X
Enriched GO Terms of Interacting Partners?		Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Regulation Of Immune System Process Interleukin-7-mediated Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Immune System Process Detection Of Bacterial Lipoprotein Negative Regulation Of Translation Involved In Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Leukocyte Activation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide RNA Destabilization Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lymph Node Development Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Interleukin-6 Biosynthetic Process Cell Activation Detection Of Bacterium Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Detection Of Biotic Stimulus Macrophage Activation Regulation Of Immune Response Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immune System Process Gene Silencing By MiRNA Negative Regulation Of Adaptive Immune Response Posttranscriptional Gene Silencing B Cell Proliferation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Stability Immunoglobulin Production Gene Silencing By RNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production
Tagcloud ?		another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses	bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal
Tagcloud (Difference) ?		another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses	bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal
Tagcloud (Intersection) ?