IL5 and S100P

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		IL5	S100P
Description		interleukin 5	S100 calcium binding protein P
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Positive Regulation Of B Cell Proliferation Interleukin-5-mediated Signaling Pathway Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Podosome Assembly	Endothelial Cell Migration
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Neutrophil degranulation
Drugs		Pranlukast Reslizumab Mepolizumab	Cromoglicic acid
Diseases
GWAS		Asthma ( 31619474 31959851) Eosinophil count ( 19198610 29403010 32888494) Inflammatory bowel disease ( 23128233) Pediatric autoimmune diseases ( 26301688) Rosacea symptom severity ( 29771307)	Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: IL5RA S100A6 S100P	46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A
Entrez ID		3567	6286
HPRD ID		00997	02792
Ensembl ID		ENSG00000113525	ENSG00000163993
Uniprot IDs		P05113	P25815
PDB IDs		1HUL 3QT2 3VA2 8TLD	1J55 1OZO 2MJW 7NMI
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Negative Regulation Of Hematopoietic Progenitor Cell Differentiation TIM23 Mitochondrial Import Inner Membrane Translocase Complex MIB Complex Negative Regulation Of Erythrocyte Differentiation SAM Complex Calcium Import Into The Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Differentiation Myeloid Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Eosinophil Differentiation Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Mitochondrial Calcium Ion Transmembrane Transport Transition Metal Ion Binding Negative Regulation Of Stem Cell Differentiation Extracellular Exosome Iron-sulfur Cluster Assembly Protein Refolding Regulation Of Interleukin-5 Production Granulocyte Differentiation Microvillus Membrane Calcium Ion Binding Protein Export From Nucleus ATP-dependent Protein Folding Chaperone Inflammatory Response To Antigenic Stimulus	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation
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