IL5 and IL5RA

Number of citations of the paper that reports this interaction (PMID 1732409)
29

Data Source:
HPRD (in vivo, in vitro)

		IL5	IL5RA
Gene Name		interleukin 5	interleukin 5 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity	Interleukin-5 Receptor Activity Protein Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Podosome Assembly	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Proliferation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Pranlukast
Diseases
GWAS		Eosinophil counts ( 19198610) Inflammatory bowel disease ( 23128233)	Asthma (childhood onset) ( 22560479) Immune response to smallpox vaccine (IL-6) ( 22542470) Oleic acid (18:1n-9) plasma levels ( 23362303)
Protein-Protein Interactions		1 interactors: IL5RA	6 interactors: CSF2RB IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		3567	3568
HPRD ID		00997	00998
Ensembl ID		ENSG00000113525	ENSG00000091181
Uniprot IDs		P05113	Q01344 Q8NHV7
PDB IDs		1HUL 3QT2 3VA2	1OBX 1OBZ 3QT2 3VA2
Enriched GO Terms of Interacting Partners?		Interleukin-5-mediated Signaling Pathway Regulation Of Interleukin-5 Production Inflammatory Response To Antigenic Stimulus	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Cytokine Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Organelle Assembly Positive Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Secretion Regulation Of Cellular Amino Acid Metabolic Process Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Signal Transduction Regulation Of Phosphorylation Regulation Of Cellular Ketone Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Regulation Of JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Eosinophil Differentiation Host Programmed Cell Death Induced By Symbiont Negative Regulation Of Clathrin-mediated Endocytosis Histone H3-Y41 Phosphorylation Regulation Of Secretion Interferon-gamma-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Cellular Response To Stimulus Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Mineralocorticoid Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Cellular Response To Interferon-gamma Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Interleukin-12-mediated Signaling Pathway Cytokinesis, Completion Of Separation Positive Regulation Of Intracellular Signal Transduction Response To Interferon-gamma Cell Migration Response To Toxic Substance Positive Regulation Of Extracellular Vesicular Exosome Assembly Interleukin-2-mediated Signaling Pathway
Tagcloud ?		1e6 adhesion airway airways bal bronchial bronchoalveolar eosinophil eosinophilia eosinophils epo examines fluid guinea hp1 hyperresponsiveness infiltration intraairway intranasally isotype lavage mab peroxidase pig reactivity seems vasculature vehicle vla	adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Difference) ?		1e6 adhesion airway airways bal bronchial bronchoalveolar eosinophil eosinophilia eosinophils epo examines fluid guinea hp1 hyperresponsiveness infiltration intraairway intranasally isotype lavage mab peroxidase pig reactivity seems vasculature vehicle vla	adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Intersection) ?