IL5 and IL5RA

Number of citations: 59 (PubMedID 1732409)
Data Source: HPRD (in vitro, in vivo)

		IL5	IL5RA
Name		interleukin 5	interleukin 5 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Positive Regulation Of B Cell Proliferation Interleukin-5-mediated Signaling Pathway Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Podosome Assembly	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Pranlukast Reslizumab Mepolizumab	Dimethyl sulfoxide Benralizumab
GWAS		Asthma ( 31619474 31959851 ) Eosinophil count ( 19198610 29403010 32888494 ) Inflammatory bowel disease ( 23128233 ) Pediatric autoimmune diseases ( 26301688 ) Rosacea symptom severity ( 29771307 )	Asthma (childhood onset) ( 22560479 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Blood protein levels ( 30072576 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Metabolite levels ( 23823483 ) Neutrophil percentage of granulocytes ( 27863252 ) Oleic acid (18:1n-9) levels ( 23362303 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		1 novel interactors: HSPA9	None recorded
Interacting Genes		3 interacting genes: IL5RA S100A6 S100P	7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		3567	3568
HPRD ID		00997	00998
Ensembl ID		ENSG00000113525	ENSG00000091181
Uniprot IDs		P05113	Q01344 Q8NHV7
PDB IDs		1HUL 3QT2 3VA2 8TLD	1OBX 1OBZ 3QT2 3VA2 6H41 8TLD
GO Terms Enriched among Interactors		Calcium-dependent Protein Binding Negative Regulation Of Hematopoietic Progenitor Cell Differentiation TIM23 Mitochondrial Import Inner Membrane Translocase Complex MIB Complex Negative Regulation Of Erythrocyte Differentiation SAM Complex Calcium Import Into The Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Differentiation Myeloid Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Eosinophil Differentiation Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Mitochondrial Calcium Ion Transmembrane Transport Transition Metal Ion Binding Negative Regulation Of Stem Cell Differentiation Extracellular Exosome Iron-sulfur Cluster Assembly Protein Refolding Regulation Of Interleukin-5 Production Granulocyte Differentiation Microvillus Membrane Calcium Ion Binding Protein Export From Nucleus ATP-dependent Protein Folding Chaperone Inflammatory Response To Antigenic Stimulus	Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Binding Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Interleukin-3 Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Binding Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Focal Adhesion Regulation Of Phosphorylation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein Tyrosine Kinase Activity Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Regulation Of Phosphorus Metabolic Process Growth Hormone Receptor Signaling Pathway Signal Transduction Membrane Raft Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Response To Antibiotic Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Multivesicular Body, Internal Vesicle Lumen Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Negative Regulation Of Endocytosis Interleukin-5 Receptor Complex Cellular Response To Cytokine Stimulus