IL5

Name	interleukin 5
Structure
Novel Interactors	1 novel interactors: HSPA9
Interactors	3 interactors: IL5RA S100A6 S100P
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Positive Regulation Of B Cell Proliferation Interleukin-5-mediated Signaling Pathway Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Podosome Assembly
Pathways	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs	Pranlukast Reslizumab Mepolizumab
GWAS	Asthma ( 31619474 31959851 ) Eosinophil count ( 19198610 29403010 32888494 ) Inflammatory bowel disease ( 23128233 ) Pediatric autoimmune diseases ( 26301688 ) Rosacea symptom severity ( 29771307 )
Entrez ID	3567
HPRD ID	00997
Ensembl ID	ENSG00000113525
Uniprot IDs	P05113
PDB IDs	1HUL 3QT2 3VA2 8TLD
GO Terms Enriched among Interactors ?	Calcium-dependent Protein Binding Negative Regulation Of Hematopoietic Progenitor Cell Differentiation TIM23 Mitochondrial Import Inner Membrane Translocase Complex MIB Complex Negative Regulation Of Erythrocyte Differentiation SAM Complex Calcium Import Into The Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Differentiation Myeloid Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Eosinophil Differentiation Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Mitochondrial Calcium Ion Transmembrane Transport Transition Metal Ion Binding Negative Regulation Of Stem Cell Differentiation Extracellular Exosome Iron-sulfur Cluster Assembly Protein Refolding Regulation Of Interleukin-5 Production Granulocyte Differentiation Microvillus Membrane Calcium Ion Binding Protein Export From Nucleus ATP-dependent Protein Folding Chaperone Inflammatory Response To Antigenic Stimulus