ICAM1 and MSN

Number of citations of the paper that reports this interaction (PMID 12082081)
93

Data Source:
HPRD (in vitro, in vivo)

		ICAM1	MSN
Gene Name		intercellular adhesion molecule 1	moesin
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Uropod Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium Microvillus Membrane Vesicle Apical Part Of Cell Extracellular Vesicular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding	Double-stranded RNA Binding Actin Binding Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Movement Of Cell Or Subcellular Component Leukocyte Cell-cell Adhesion Positive Regulation Of Gene Expression Membrane To Membrane Docking Leukocyte Migration Establishment Of Endothelial Barrier Regulation Of Lymphocyte Migration
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Axon guidance L1CAM interactions Recycling pathway of L1
Drugs		Natalizumab Hyaluronan
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN	24 interactors: BCAP31 CD44 CD46 CD93 CDK11B EZR ICAM1 ICAM2 ICAM3 L1CAM NCF1 NCF4 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SPN TERF1 TSC1 VCAM1
Entrez ID		3383	4478
HPRD ID		00996	02399
Ensembl ID		ENSG00000090339	ENSG00000147065
Uniprot IDs		B4DQW5 E7ESS4 P05362	P26038
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX	1E5W 1EF1 1SGH
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation	Membrane To Membrane Docking Single Organismal Cell-cell Adhesion Cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Cellular Extravasation Membrane Docking Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Cell-cell Adhesion Locomotion Regulation Of Immune System Process Regulation Of T Cell Proliferation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Execution Phase Of Apoptosis Cell Migration Regulation Of Cell-cell Adhesion Cell Motility Positive Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Immune Response Apoptotic Process Blood Coagulation Inflammatory Response Hemostasis Cell Activation Programmed Cell Death Cell Death Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Signal Transduction Leukocyte Activation Interferon-gamma-mediated Signaling Pathway Response To Stimulus Regulation Of T Cell Activation Innate Immune Response Positive Regulation Of Cell Activation Negative Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels
Tagcloud ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Difference) ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Intersection) ?