ICAM1 and IL2RA

Number of citations: 33 (PubMedID 1976256)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		ICAM1	IL2RA
Name		intercellular adhesion molecule 1	interleukin 2 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Immune System Process Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Regulation Of Immune System Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Natalizumab Hyaluronic acid Nafamostat	Denileukin diftitox Aldesleukin Basiliximab Daclizumab Inolimomab Camidanlumab tesirine
Diseases		Allograft rejection	Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 ) Height ( 31562340 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low white blood cell count (conditioned on rs2814778) ( 29596498 ) Lymphocyte count ( 27863252 32888494 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Soluble ICAM-1 ( 18604267 21533024 31217265 ) White blood cell count ( 32888494 )	Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Alopecia areata ( 20596022 25608926 ) Arthritis (juvenile idiopathic) ( 33106285 ) Asthma ( 34103634 31959851 31619474 31361310 30929738 32296059 ) Asthma (adult onset) ( 30929738 ) Asthma (bronchodilator response) ( 23508266 ) Asthma (childhood onset) ( 30929738 ) Asthma and hay fever ( 24388013 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Autoimmune traits (pleiotropy) ( 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 21102463 ) Diisocyanate-induced asthma ( 25918132 ) Eczema ( 31361310 ) Emotional dysregulation ( 27643478 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262 ) Graves' disease ( 22922229 ) Inflammatory biomarkers ( 22228203 ) Inflammatory bowel disease ( 23128233 ) Interleukin-2 receptor antagonist levels ( 27989323 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Marginal zone lymphoma or multiple sclerosis ( 31407831 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 19525953 17660530 19525955 21833088 28445677 24076602 22190364 27386562 ) Neutrophil percentage of white cells ( 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Plasma t-tau levels ( 28100725 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Rheumatoid arthritis ( 30572963 30423114 24449572 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Selective IgA deficiency ( 27723758 ) Soluble interleukin-2 receptor subunit alpha ( 26293465 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 30572963 25751624 22293688 21829393 19430480 18978792 ) Vitiligo ( 27723757 20410501 ) White blood cell count ( 32888494 )
Novel Interactors		12 novel interactors: BCL7B BRAF CALR FANCF HDAC1 KIF1A MAP2K7 MC1R MTPN MYO1F SLCO2B1 TBL3	9 novel interactors: AKR1C3 ARHGAP12 CALML3 FGF12 FKBP4 GTPBP4 JCAD KIN PFKP
Interacting Genes		16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2	8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		3383	3559
HPRD ID		00996	00986
Ensembl ID		ENSG00000090339	ENSG00000134460
Uniprot IDs		A0A384MEK5 P05362	H0Y5Z0 P01589 Q5W005
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO 7F9W 7ZMZ
GO Terms Enriched among Interactors		Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion	Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Binding Cytokine-mediated Signaling Pathway Response To Peptide Response To Cytokine Positive Regulation Of Inflammatory Response Cellular Response To Interleukin-17 Activated T Cell Proliferation Cellular Response To Cytokine Stimulus Regulation Of Vitamin Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Immune Response Progesterone Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Alcohol Regulation Of Monoatomic Cation Transmembrane Transport Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cell Population Proliferation Response To Estradiol Positive Regulation Of T Cell Proliferation Adaptive Immune Response Positive Regulation Of Myeloid Cell Differentiation T Cell Activation Positive Regulation Of B Cell Differentiation Transcription By RNA Polymerase II Negative Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Response To Ethanol Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process Regulation Of Metal Ion Transport Sex Differentiation Positive Regulation Of Activated T Cell Proliferation Cellular Response To Hormone Stimulus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Transport Sodium Channel Regulator Activity Immune Effector Process Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Interleukin-2 Production Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Inflammatory Response