ICAM1 and MYO1F

Data Source: HiPPIP (Novel)

		ICAM1	MYO1F
Name		intercellular adhesion molecule 1	myosin IF
Structure			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Microvillus Actin Cytoskeleton Myosin Complex Unconventional Myosin Complex
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Endocytosis Actin Filament Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	None
Drugs		Natalizumab Hyaluronic acid Nafamostat	None
Diseases		Allograft rejection	None
GWAS		Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 ) Height ( 31562340 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low white blood cell count (conditioned on rs2814778) ( 29596498 ) Lymphocyte count ( 27863252 32888494 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Soluble ICAM-1 ( 18604267 21533024 31217265 ) White blood cell count ( 32888494 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 18391951 28552196 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Monocyte percentage of white cells ( 32888494 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 )
Novel Interactors		12 novel interactors: BCL7B BRAF CALR FANCF HDAC1 KIF1A MAP2K7 MC1R MTPN MYO1F SLCO2B1 TBL3	3 novel interactors: ICAM1 PDZD11 RFX2
Interacting Genes		16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2	5 interacting genes: ATOSB EWSR1 IRF9 SCNM1 SH3BP2
Entrez ID		3383	4542
HPRD ID		00996	03282
Ensembl ID		ENSG00000090339	ENSG00000142347
Uniprot IDs		A0A384MEK5 P05362	O00160
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7	Not available
GO Terms Enriched among Interactors		Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion	None