RGS20 and AQP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RGS20	AQP1
Gene Name		regulator of G-protein signaling 20	aquaporin 1 (Colton blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Axon Terminus Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	Intracellular CGMP Activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Ephrin Receptor Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Renal Water Homeostasis Glomerular Filtration Renal Water Transport CGMP Biosynthetic Process Potassium Ion Transport Water Transport Cell Volume Homeostasis Cellular Water Homeostasis Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial Cell Migration Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Sensory Perception Of Pain Cellular Homeostasis Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To Stress Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Response To Drug Hyperosmotic Salinity Response Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Estrogen Lipid Digestion Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Multicellular Organismal Water Homeostasis Corticotropin Secretion Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host Cation Transmembrane Transport
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events	O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Erythrocytes take up oxygen and release carbon dioxide Aquaporin-mediated transport
Drugs			Acetazolamide
Diseases
GWAS			Nephrolithiasis ( 22396660)
Protein-Protein Interactions		33 interactors: ADRB2 AQP1 CATSPER1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-6 KRTAP5-9 LCE1B LCE2A LCE2D LCE3E LCE4A MAPKBP1 OSTM1 OTX1 PTGER3 PTPMT1 PVRL3 STMN2 TBC1D16	42 interactors: ADAMTSL4 CCDC136 CCDC36 CCDC57 CCDC85B CEP44 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 MDFI MID2 MTUS2 NBPF22P NOTCH2NL PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6
Entrez ID		8601	358
HPRD ID		06225	00140
Ensembl ID		ENSG00000147509	ENSG00000240583
Uniprot IDs		H9NIM5 O76081	B4DPF5 B4E3E3 P29972
PDB IDs			1FQY 1H6I 1IH5
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Keratinization Keratinocyte Differentiation Epidermis Development Developmental Process Epidermal Cell Differentiation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Organ Development System Development Multicellular Organismal Development Anatomical Structure Development Skin Development Heat Generation G-protein Coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Tissue Development Regulation Of CAMP Biosynthetic Process Epithelium Development Regulation Of CAMP Metabolic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Epithelial Cell Differentiation Temperature Homeostasis Membrane Fusion Regulation Of Body Fluid Levels Cell-cell Signaling Negative Regulation Of CAMP Biosynthetic Process Sensory Organ Development Wound Healing Bicarbonate Transport Negative Regulation Of CAMP Metabolic Process Eye Morphogenesis Cell Activation Negative Regulation Of Nucleotide Metabolic Process Acute-phase Response Regulation Of Catalytic Activity Response To Wounding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation B Cell Cytokine Production Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Isotype Switching To IgG Isotypes Anion Homeostasis	Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Binding Developmental Process Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Axonal Fasciculation Embryonic Organ Morphogenesis Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Binding Cell Differentiation Regulation Of Cellular Process Face Morphogenesis Neuron Recognition Regulation Of Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Head Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Signaling Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Communication Negative Regulation Of Signaling Face Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Cellular Response To Extracellular Stimulus Embryonic Organ Development I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Fat Cell Differentiation Body Morphogenesis DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Termination Of Signal Transduction Toll-like Receptor 3 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?			2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Difference) ?			2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Intersection) ?