RGS20 and PTGER3

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		RGS20	PTGER3
Name		regulator of G protein signaling 20	prostaglandin E receptor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Plasma Membrane Membrane	Nuclear Envelope Plasma Membrane Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Death Intestine Smooth Muscle Contraction Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion
Pathways		G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events	Prostanoid ligand receptors G alpha (i) signalling events
Drugs		None	Bimatoprost Dinoprostone Misoprostol Trichostatin A Gemeprost Limaprost Castor oil Rivenprost
GWAS		Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835 ) Chronic obstructive pulmonary disease ( 32222710 ) Serum uric acid levels ( 29559957 ) Urinary albumin-to-creatinine ratio ( 26631737 )	Alcohol use disorder (consumption score) ( 33861876 ) Colon cancer ( 33632709 ) Dental caries (decayed, missing and filled teeth) ( 31533690 ) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821 ) Intelligence (MTAG) ( 29326435 ) Proximal colorectal cancer ( 33632709 ) Verbal declarative memory ( 25648963 )
Interacting Genes		58 interacting genes: ABHD17A ADRB2 ALPP AQP1 CATSPER1 COL8A1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HRG HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAPKBP1 NECTIN2 NECTIN3 NEK8 NUFIP2 OSTM1 OTX1 PTGER3 PTPMT1 RANBP3 STMN2 TBC1D16 VASN	23 interacting genes: ADAMTSL4 CCDC33 CDA EFEMP2 INCA1 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MEOX2 MGAT5B MKLN1 NOTCH2NLA PTGER1 REL RGS17 RGS20 SPRY2 TCF4 TRIM42
Entrez ID		8601	5733
HPRD ID		06225	08906
Ensembl ID		ENSG00000147509	ENSG00000050628
Uniprot IDs		B3KSW4 H9NIM5 O76081	O00325 P43115
PDB IDs		Not available	6AK3 6M9T 7WU9 8GDC
GO Terms Enriched among Interactors		Keratinization Epidermis Development Tissue Development Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Intermediate Filament Heterotrimeric G-protein Complex Identical Protein Binding Protein Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Positive Regulation Of Immune Response To Tumor Cell G Protein-coupled Serotonin Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity G Protein-coupled Receptor Binding Negative Regulation Of Protein Secretion Regulation Of Response To Tumor Cell Negative Regulation Of Secretion By Cell Negative Regulation Of Insulin Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Peptide Secretion Hippocampal Mossy Fiber To CA3 Synapse Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Protein Transport Negative Regulation Of Protein Localization Developmental Process Adhesion Of Symbiont To Host	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Tissue Morphogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process