RGS20 and NEK8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RGS20	NEK8
Description		regulator of G protein signaling 20	NIMA related kinase 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Plasma Membrane Membrane	Cytoplasm Centrosome Cytoskeleton Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling Animal Organ Development
Pathways		G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic obstructive pulmonary disease ( 32222710) Serum uric acid levels ( 29559957) Urinary albumin-to-creatinine ratio ( 26631737)	Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		58 interacting genes: ABHD17A ADRB2 ALPP AQP1 CATSPER1 COL8A1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HRG HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAPKBP1 NECTIN2 NECTIN3 NEK8 NUFIP2 OSTM1 OTX1 PTGER3 PTPMT1 RANBP3 STMN2 TBC1D16 VASN	11 interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC
Entrez ID		8601	284086
HPRD ID		06225	14822
Ensembl ID		ENSG00000147509	ENSG00000160602
Uniprot IDs		B3KSW4 H9NIM5 O76081	Q86SG6
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Intermediate Filament Heterotrimeric G-protein Complex Identical Protein Binding Protein Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Positive Regulation Of Immune Response To Tumor Cell G Protein-coupled Serotonin Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity G Protein-coupled Receptor Binding Negative Regulation Of Protein Secretion Regulation Of Response To Tumor Cell Negative Regulation Of Secretion By Cell Negative Regulation Of Insulin Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Peptide Secretion Hippocampal Mossy Fiber To CA3 Synapse Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Protein Transport Negative Regulation Of Protein Localization Developmental Process Adhesion Of Symbiont To Host	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Pigment Cell Development 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Beta-catenin-TCF7L2 Complex Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Complex TFIIB-class Transcription Factor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Atrial Septum Primum Morphogenesis Endocardial Cushion Fusion Ameboidal-type Cell Migration Protein Kinase Activity Cell Adhesion Involved In Heart Morphogenesis Myofibroblast Differentiation Parathyroid Gland Development Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Extrinsic Apoptotic Signaling Pathway BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Mitral Valve Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation
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