APOH and GEM

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		APOH	GEM
Description		apolipoprotein H	GTP binding protein overexpressed in skeletal muscle
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Exosome	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Lipase Binding Identical Protein Binding Lipoprotein Lipase Activator Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Positive Regulation Of Triglyceride Metabolic Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment
Pathways		Platelet degranulation	NPAS4 regulates expression of target genes
Drugs		LJP 1082 Copper
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Alanine aminotransferase levels ( 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531)	Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 OGT PLG RBBP6	128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9
Entrez ID		350	2669
HPRD ID		00728	11553
Ensembl ID		ENSG00000091583	ENSG00000164949
Uniprot IDs		A0A384NKM6 P02749	P55040
PDB IDs		1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09 6XSD 6XST 7JIK 7KG4	2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?		Fibrinolysis Apolipoprotein Binding Proteolysis Serine-type Peptidase Activity Positive Regulation Of Fibrinolysis Plasma Membrane Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Proteolysis Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Maturation Positive Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of TOR Signaling Glutamatergic Synapse Regulation Of Body Fluid Levels Low-density Lipoprotein Particle Receptor Activity Regulation Of Cell Migration Regulation Of Synapse Organization Regulation Of Plasminogen Activation Calcium Ion Binding Coagulation Blood Coagulation Regulation Of Fibrinolysis Regulation Of Cell Motility Hemostasis Protein Maturation Regulation Of Locomotion Regulation Of Multicellular Organismal Process Labyrinthine Layer Blood Vessel Development External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process Regulation Of Wound Healing Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Spindle Midzone Positive Regulation Of Blood Coagulation Cargo Receptor Activity Blood Vessel Development Regulation Of TOR Signaling Positive Regulation Of Coagulation Embryonic Organ Development Placenta Blood Vessel Development Regulation Of Cell Adhesion	Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton
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