APOH and LRP8

Number of citations of the paper that reports this interaction (PMID 12807892)
15

Data Source:
HPRD (in vivo)

		APOH	LRP8
Gene Name		apolipoprotein H (beta-2-glycoprotein I)	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cell Surface Extracellular Matrix Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Glycoprotein Binding Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Identical Protein Binding Lipoprotein Lipase Activator Activity	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Triglyceride Metabolic Process Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Lipoprotein Lipase Activity Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways			Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374)	Body mass index (interaction) ( 23192594)
Protein-Protein Interactions		14 interactors: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 PLG RBBP6 TP53	19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		350	7804
HPRD ID		00728	04002
Ensembl ID		ENSG00000091583
Uniprot IDs		P02749	Q14114
PDB IDs		1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS	3A7Q
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Fibrinolysis Positive Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Response To Radiation Negative Regulation Of Wound Healing Labyrinthine Layer Development Organ Development Embryonic Organ Development Vesicle-mediated Transport Immune System Process In Utero Embryonic Development T Cell Costimulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Blood Coagulation Endocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Fibrinolysis Positive Regulation Of Protein Phosphorylation Response To Light Stimulus Multicellular Organism Growth Embryonic Placenta Development Immune Response Receptor-mediated Endocytosis Regulation Of Phosphorylation Blood Coagulation, Intrinsic Pathway Regulation Of Wound Healing Regulation Of Cell-cell Adhesion Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Organelle Organization System Development Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Modification Process Labyrinthine Layer Blood Vessel Development Regulation Of Organelle Organization Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Growth	Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?		avoiding cdc42 crosstalk dialog diffusible genomics germ highlighting inaccessible integrative interactomics interlaced juxtacrine membranome microsurgery mining ngfr omics pla secretome secretomes seminiferous sertoli spermatogenesis surrounded testicular tf transcriptomics tubules	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Difference) ?		avoiding cdc42 crosstalk dialog diffusible genomics germ highlighting inaccessible integrative interactomics interlaced juxtacrine membranome microsurgery mining ngfr omics pla secretome secretomes seminiferous sertoli spermatogenesis surrounded testicular tf transcriptomics tubules	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Intersection) ?