FFAR2 and KRT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FFAR2	KRT1
Description		free fatty acid receptor 2	keratin 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Cell Projection	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Immune System Process Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Insulin Secretion Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-8 Production Glucose Homeostasis Fat Cell Differentiation Negative Regulation Of Insulin Secretion Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Ligand-gated Ion Channel Signaling Pathway	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier
Pathways		G alpha (q) signalling events Free fatty acid receptors	Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		GLPG-0974	Zinc Copper Zinc acetate
Diseases			Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
GWAS		Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		120 interacting genes: AGPAT4 AGTRAP ALOX5AP ANKRD46 APOD ARLN ATP13A1 ATP6V0C BMP10 BNIP3 BTN2A2 C11orf24 C3orf52 CACNG1 CATSPERH CBLIF CCDC167 CD82 CDIPT CFHR5 CGRRF1 CLDN4 CLDND2 CLEC1A CMTM5 CMTM7 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB5R2 DERL1 EDDM3B EMC6 EMP1 ERG28 FAM20B FAM3C FAXDC2 FCER1G FIS1 FXYD3 FXYD6 FZD7 GALNT15 GJB2 GNAO1 GNAQ GPR37L1 GUCA2A GYPA IFITM3 IGF1R IGFBP5 KRT1 KTN1 LAPTM4A LAT LEPROTL1 LHFPL5 LPAR3 MALL MS4A13 NAT8 NIPAL4 NKG7 NRM NSG1 NUCB2 OR10AG1 PEX16 PLP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SACM1L SCGB1D1 SELENOK SERP2 SLC30A2 SLC35B4 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A9 SLC41A1 SLC61A1 SMAGP SMCO4 SMIM1 STRIT1 STX8 SYNDIG1 TEX264 TM4SF4 TMEM11 TMEM120B TMEM128 TMEM144 TMEM147 TMEM203 TMEM218 TMEM229B TMEM239 TMEM243 TMEM60 TMEM86A TMEM86B TMEM97 TNF TSPO2 UNC50 UPK1B YIF1A YIPF2 YIPF6	54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 OGT PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ
Entrez ID		2867	3848
HPRD ID		04824	00763
Ensembl ID		ENSG00000126262	ENSG00000167768
Uniprot IDs		C6KYL4 O15552	P04264
PDB IDs		8J22 8J23 8J24 8T3S 9K1D	4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Bleb Assembly Alkenylglycerophosphocholine Hydrolase Activity Transmembrane Transport	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex
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