FFAR2 and PLP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FFAR2	PLP1
Description		free fatty acid receptor 2	proteolipid protein 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Cell Projection	Plasma Membrane Membrane Myelin Sheath Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Immune System Process Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Insulin Secretion Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-8 Production Glucose Homeostasis Fat Cell Differentiation Negative Regulation Of Insulin Secretion Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Ligand-gated Ion Channel Signaling Pathway	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development
Pathways		G alpha (q) signalling events Free fatty acid receptors
Drugs		GLPG-0974
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		120 interacting genes: AGPAT4 AGTRAP ALOX5AP ANKRD46 APOD ARLN ATP13A1 ATP6V0C BMP10 BNIP3 BTN2A2 C11orf24 C3orf52 CACNG1 CATSPERH CBLIF CCDC167 CD82 CDIPT CFHR5 CGRRF1 CLDN4 CLDND2 CLEC1A CMTM5 CMTM7 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB5R2 DERL1 EDDM3B EMC6 EMP1 ERG28 FAM20B FAM3C FAXDC2 FCER1G FIS1 FXYD3 FXYD6 FZD7 GALNT15 GJB2 GNAO1 GNAQ GPR37L1 GUCA2A GYPA IFITM3 IGF1R IGFBP5 KRT1 KTN1 LAPTM4A LAT LEPROTL1 LHFPL5 LPAR3 MALL MS4A13 NAT8 NIPAL4 NKG7 NRM NSG1 NUCB2 OR10AG1 PEX16 PLP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SACM1L SCGB1D1 SELENOK SERP2 SLC30A2 SLC35B4 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A9 SLC41A1 SLC61A1 SMAGP SMCO4 SMIM1 STRIT1 STX8 SYNDIG1 TEX264 TM4SF4 TMEM11 TMEM120B TMEM128 TMEM144 TMEM147 TMEM203 TMEM218 TMEM229B TMEM239 TMEM243 TMEM60 TMEM86A TMEM86B TMEM97 TNF TSPO2 UNC50 UPK1B YIF1A YIPF2 YIPF6	91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		2867	5354
HPRD ID		04824	02321
Ensembl ID		ENSG00000126262	ENSG00000123560
Uniprot IDs		C6KYL4 O15552	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs		8J22 8J23 8J24 8T3S 9K1D	2XPG
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Bleb Assembly Alkenylglycerophosphocholine Hydrolase Activity Transmembrane Transport	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity
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