TUBB2B and RSPH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TUBB2B	RSPH1
Description		tubulin beta 2B class IIb	radial spoke head component 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Schaffer Collateral - CA1 Synapse	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Nervous System Development Cerebral Cortex Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Axon Guidance Embryonic Brain Development	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Interacting Genes		13 interacting genes: ANXA7 BID C8orf33 CACNA1A CDKN1A CENPU CSNK2B DLG4 HDAC6 OGT RGS2 RPL35 RSPH1	125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793
Entrez ID		347733	89765
HPRD ID		14707	11651
Ensembl ID		ENSG00000137285	ENSG00000160188
Uniprot IDs		A0A384MEE3 Q9BVA1	Q8WYR4
PDB IDs		6E7C 7ZCW	8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Growth Negative Regulation Of Protein Metabolic Process Dendritic Spine Morphogenesis Cytoplasm Response To Alcohol Negative Regulation Of Gene Expression Autophagy Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Cytosol Negative Regulation Of Cell Growth Protein Localization To Organelle PCNA-p21 Complex Negative Regulation Of Growth Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process P2Y1 Nucleotide Receptor Binding Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Negative Regulation Of Glycine Import Across Plasma Membrane Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Beta-tubulin Binding Response To Amine Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Autophagy Of Mitochondrion Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Cell Projection Regulation Of Developmental Growth Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization To Organelle Protein Kinase CK2 Complex Negative Regulation Of Locomotion	Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly
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