TUBB2B and BID

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TUBB2B	BID
Gene Name		tubulin, beta 2B class IIb	BH3 interacting domain death agonist
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Neuron Migration Protein Folding Microtubule-based Process Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Response To Estradiol Positive Regulation Of Protein Oligomerization Positive Regulation Of Protein Homooligomerization Glial Cell Apoptotic Process Regulation Of Cell Proliferation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Protein Homooligomerization Neuron Apoptotic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Activation of BAD and translocation to mitochondria Activation, translocation and oligomerization of BAX Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ANXA7 BID C8orf33 CACNA1A CDKN1A CENPU CSNK2B HDAC6 RGS2 RPL35	36 interactors: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 C14orf1 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		347733	637
HPRD ID		14707	03590
Ensembl ID		ENSG00000137285	ENSG00000015475
Uniprot IDs		Q9BVA1	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs			1ZY3 2BID 2KBW 2M5B 4BD2
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Positive Regulation Of Cellular Component Biogenesis Membrane Organization Regulation Of Protein Complex Assembly Cellular Response To Heat Protein Localization To Membrane Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Cerebellar Molecular Layer Development Hsp90 Deacetylation Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Vestibular Nucleus Development Polyubiquitinated Misfolded Protein Transport Response To Heat Developmental Process Regulation Of Catalytic Activity Cell Cycle Cellular Protein Localization Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Organic Substance Positive Regulation Of Programmed Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Death Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Gamma-aminobutyric Acid Secretion Regulation Of Reactive Oxygen Species Metabolic Process Autophagy Regulation Of Microtubule-based Process Regulation Of Cell Death Intestinal Epithelial Cell Maturation Regulation Of Acetylcholine Secretion, Neurotransmission Response To Toxic Substance Regulation Of Protein Kinase Activity Regulation Of Adrenergic Receptor Signaling Pathway Rhythmic Synaptic Transmission Intrinsic Apoptotic Signaling Pathway Response To Temperature Stimulus	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Mitochondrial Membrane Potential Protein Processing Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Anoikis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Neuron Apoptotic Process Regulation Of Anoikis Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Neuron Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cell Death Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cell Communication Response To Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Activation Of Cysteine-type Endopeptidase Activity Regulation Of Membrane Permeability
Tagcloud ?		200x customized dcx depths dync1h1 exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical unequal	3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar
Tagcloud (Difference) ?		200x customized dcx depths dync1h1 exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical unequal	3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar
Tagcloud (Intersection) ?