TUBB2B and C8orf33

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TUBB2B	C8orf33
Description		tubulin beta 2B class IIb	chromosome 8 open reading frame 33
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Nervous System Development Cerebral Cortex Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Axon Guidance Embryonic Brain Development
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Interacting Genes		13 interacting genes: ANXA7 BID C8orf33 CACNA1A CDKN1A CENPU CSNK2B DLG4 HDAC6 OGT RGS2 RPL35 RSPH1	50 interacting genes: AAMP ALAS1 APP BLOC1S2 BRD4 CEP70 CFTR CRELD2 DISC1 DVL3 EDRF1 EPS8 FAM9B FEZ1 FST FYN GIT1 GPRASP1 HAP1 HMBOX1 IKZF1 IMMT KBTBD7 KCTD6 KRTAP10-7 LZTS2 MAPK8IP2 MCC MDFI MRFAP1 NACC1 NGEF NOL7 PI4KA PICK1 PNMA1 RASSF1 SF3B2 TAOK1 TNIP1 TRIM23 TRIM41 TUBA1A TUBB2B WIZ ZC3H15 ZFP28 ZNF205 ZNF331 ZNF526
Entrez ID		347733	65265
HPRD ID		14707	07951
Ensembl ID		ENSG00000137285	ENSG00000182307
Uniprot IDs		A0A384MEE3 Q9BVA1	Q9H7E9
PDB IDs		6E7C 7ZCW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Growth Negative Regulation Of Protein Metabolic Process Dendritic Spine Morphogenesis Cytoplasm Response To Alcohol Negative Regulation Of Gene Expression Autophagy Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Cytosol Negative Regulation Of Cell Growth Protein Localization To Organelle PCNA-p21 Complex Negative Regulation Of Growth Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process P2Y1 Nucleotide Receptor Binding Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Negative Regulation Of Glycine Import Across Plasma Membrane Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Beta-tubulin Binding Response To Amine Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Autophagy Of Mitochondrion Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Cell Projection Regulation Of Developmental Growth Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization To Organelle Protein Kinase CK2 Complex Negative Regulation Of Locomotion	Cytoplasm Growth Cone Gamma-tubulin Binding Identical Protein Binding Protein Binding Regulation Of JNK Cascade Modulation Of Chemical Synaptic Transmission Ephrin Receptor Binding Negative Regulation Of Signaling Learning Growth Factor Receptor Binding Regulation Of Cell Communication Nucleus Negative Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Projection Organization Postsynaptic Density Protein-containing Complex Binding Centrosome Regulation Of Cell Projection Organization Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Neuron Projection Organization Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Cellular Component Organization Ephrin Receptor Signaling Pathway Dendritic Spine Maintenance Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendritic Spine Maintenance Cytosol Golgi-associated Vesicle Membrane Regulation Of Postsynapse Organization Neuron Cellular Homeostasis Regulation Of Cytoskeleton Organization Neuron Migration Microtubule Cytoskeleton Cell Projection Organization Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Neuron Projection Development Cellular Component Maintenance Regulation Of Microtubule-based Process Learning Or Memory Heparan Sulfate Proteoglycan Binding
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