KIF24 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIF24	RNF8
Description		kinesin family member 24	ring finger protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Protein-containing Complex	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule-based Movement Microtubule Depolymerization Cell Projection Organization Cilium Assembly Negative Regulation Of Cilium Assembly	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		Anchoring of the basal body to the plasma membrane	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Fruit consumption ( 32066663)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		14 interacting genes: AP1M1 CSNK2A1 CWF19L2 EXOSC7 HSF2BP KAT5 LNX1 MYO15B NXF1 PRKAA2 PRPF6 RANBP3L RNF8 SYT6	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		347240	9025
HPRD ID		12963	11521
Ensembl ID		ENSG00000186638	ENSG00000112130
Uniprot IDs		Q5T7B8	O76064
PDB IDs			2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Protein Localization To Site Of Double-strand Break Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Double-strand Break Repair Phosphatidylethanolamine Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Aggrephagy Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Macroautophagy Protein Localization To Chromosome Sperm DNA Condensation Phosphatidylcholine Biosynthetic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Intracellular Protein Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Phosphatidylethanolamine Metabolic Process DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Autophagy Regulation Of Macroautophagy Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Lipid Droplet Organization Negative Regulation Of DNA Repair DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Myoblast Differentiation Negative Regulation Of Translational Initiation Negative Regulation Of DNA Recombination Protein Targeting To Vacuole Regulation Of DNA Repair Intracellular Protein Transport Cellular Response To Glucose Starvation Histone H2AK5 Acetyltransferase Activity DNA Recombination Macromolecule Catabolic Process Nucleoplasm Establishment Of Protein Localization To Vacuole Protein Transport MRNA Metabolic Process Cellular Response To Glucose Stimulus Phosphatidylcholine Metabolic Process Protein Localization To Organelle Autophagy Cellular Response To Carbohydrate Stimulus [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?