KIF24 and PRPF6

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		KIF24	PRPF6
Description		kinesin family member 24	pre-mRNA processing factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Protein-containing Complex	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Microtubule-based Movement Microtubule Depolymerization Cell Projection Organization Cilium Assembly Negative Regulation Of Cilium Assembly	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Anchoring of the basal body to the plasma membrane	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Fruit consumption ( 32066663)	Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: AP1M1 CSNK2A1 CWF19L2 EXOSC7 HSF2BP KAT5 LNX1 MYO15B NXF1 PRKAA2 PRPF6 RANBP3L RNF8 SYT6	67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2
Entrez ID		347240	24148
HPRD ID		12963	10729
Ensembl ID		ENSG00000186638	ENSG00000101161
Uniprot IDs		Q5T7B8	O94906
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Protein Localization To Site Of Double-strand Break Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Double-strand Break Repair Phosphatidylethanolamine Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Aggrephagy Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Macroautophagy Protein Localization To Chromosome Sperm DNA Condensation Phosphatidylcholine Biosynthetic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Intracellular Protein Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Phosphatidylethanolamine Metabolic Process DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Autophagy Regulation Of Macroautophagy Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Lipid Droplet Organization Negative Regulation Of DNA Repair DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Myoblast Differentiation Negative Regulation Of Translational Initiation Negative Regulation Of DNA Recombination Protein Targeting To Vacuole Regulation Of DNA Repair Intracellular Protein Transport Cellular Response To Glucose Starvation Histone H2AK5 Acetyltransferase Activity DNA Recombination Macromolecule Catabolic Process Nucleoplasm Establishment Of Protein Localization To Vacuole Protein Transport MRNA Metabolic Process Cellular Response To Glucose Stimulus Phosphatidylcholine Metabolic Process Protein Localization To Organelle Autophagy Cellular Response To Carbohydrate Stimulus [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway
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