KIF24 and PRKAA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KIF24	PRKAA2
Description		kinesin family member 24	protein kinase AMP-activated catalytic subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Ciliary Basal Body Neuronal Cell Body
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity
	Biological Process	Microtubule-based Movement Microtubule Depolymerization Cell Projection Organization Cilium Assembly Negative Regulation Of Cilium Assembly	Cytoplasmic Translation Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Sterol Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Rhythmic Process Fatty Acid Homeostasis Protein Localization To Lysosome Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet
Pathways		Anchoring of the basal body to the plasma membrane	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs Nuclear events mediated by NFE2L2 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Fruit consumption ( 32066663)	Lymphocyte count ( 22286170)
Interacting Genes		14 interacting genes: AP1M1 CSNK2A1 CWF19L2 EXOSC7 HSF2BP KAT5 LNX1 MYO15B NXF1 PRKAA2 PRPF6 RANBP3L RNF8 SYT6	122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SAXO4 SERTAD3 SKIC2 SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBC UBE2I USH1C USH1G USHBP1 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23
Entrez ID		347240	5563
HPRD ID		12963	02735
Ensembl ID		ENSG00000186638	ENSG00000162409
Uniprot IDs		Q5T7B8	P54646
PDB IDs			2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Protein Localization To Site Of Double-strand Break Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Double-strand Break Repair Phosphatidylethanolamine Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Aggrephagy Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Macroautophagy Protein Localization To Chromosome Sperm DNA Condensation Phosphatidylcholine Biosynthetic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Intracellular Protein Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Phosphatidylethanolamine Metabolic Process DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Autophagy Regulation Of Macroautophagy Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Lipid Droplet Organization Negative Regulation Of DNA Repair DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Myoblast Differentiation Negative Regulation Of Translational Initiation Negative Regulation Of DNA Recombination Protein Targeting To Vacuole Regulation Of DNA Repair Intracellular Protein Transport Cellular Response To Glucose Starvation Histone H2AK5 Acetyltransferase Activity DNA Recombination Macromolecule Catabolic Process Nucleoplasm Establishment Of Protein Localization To Vacuole Protein Transport MRNA Metabolic Process Cellular Response To Glucose Stimulus Phosphatidylcholine Metabolic Process Protein Localization To Organelle Autophagy Cellular Response To Carbohydrate Stimulus [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity	Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cytosol Supramolecular Fiber Organization Cytoplasm Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Malonyl-CoA Biosynthetic Process Acetyl-CoA Carboxylase Activity Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Prolactin Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytoskeleton Cellular Component Assembly Autophagy Regulation Of Growth Transcription Factor Binding Equilibrioception Keratin Filament Microtubule Motor Activity Cullin Family Protein Binding Microtubule
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