IFNGR2 and ANXA5

Number of citations of the paper that reports this interaction (PMID 16670301)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		IFNGR2	ANXA5
Gene Name		interferon gamma receptor 2 (interferon gamma transducer 1)	annexin A5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Intracellular Cytoplasm Focal Adhesion External Side Of Plasma Membrane Membrane Extracellular Vesicular Exosome Endothelial Microparticle
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipid Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Signal Transduction Blood Coagulation Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Coagulation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		Interferon gamma-1b
Diseases
GWAS		Crohn's disease ( 22936669 23128233) Obesity-related traits ( 23251661)	Chronic obstructive pulmonary disease ( 21685187)
Protein-Protein Interactions		8 interactors: ANXA5 CAMK2D DNAJA3 IFNG IFNGR1 JAK2 NR3C1 RPL37A	17 interactors: ACTG1 APP COL10A1 COL2A1 EED EIF4G1 FDFT1 IFNGR2 ITGB5 KDR LAMC3 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2
Entrez ID		3460	308
HPRD ID		00956	00568
Ensembl ID		ENSG00000159128	ENSG00000164111
Uniprot IDs		A8K881 E7EUY1 P38484	P08758
PDB IDs			1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3
Enriched GO Terms of Interacting Partners?		Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Innate Immune Response Response To Organic Substance Response To Cytokine Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Cell Death Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Positive Regulation Of Phosphatase Activity Regulation Of The Force Of Heart Contraction Positive Regulation Of Interleukin-1 Production Regulation Of Cell Death Homeostasis Of Number Of Cells Regulation Of Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Dephosphorylation Regulation Of Interleukin-1 Beta Production Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Tumor Necrosis Factor Production Establishment Of Protein Localization To Organelle Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Steroid Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Signaling	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomerase Extracellular Matrix Organization Extracellular Structure Organization Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization RNA-dependent DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome Telomeric Loop Formation Age-dependent Telomere Shortening Homeostatic Process Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Regulation Of DNA Replication Anatomical Structure Morphogenesis Positive Regulation Of Organelle Organization Tissue Homeostasis Regulation Of Organelle Organization Negative Regulation Of Cellular Metabolic Process Endochondral Ossification Multicellular Organismal Homeostasis Organelle Organization Chromatin Modification Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere DNA Replication Collagen Catabolic Process Cell Development Cell Aging Chromatin Organization Cell Morphogenesis Involved In Differentiation Collagen Metabolic Process Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Developmental Process MRNA 3'-end Processing
Tagcloud ?		allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	a2 alkaline altered annexin annexins anxa2 bglap col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	a2 alkaline altered annexin annexins anxa2 bglap col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Intersection) ?