IFNGR2 and PMP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IFNGR2	PMP22
Description		interferon gamma receptor 2	peripheral myelin protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse
	Molecular Function	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding	Protein Binding
	Biological Process	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Defense Response To Virus Type II Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Glutamate Receptor Signaling Pathway	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22936669 23128233 28067908) Diverticular disease ( 30177863) Educational attainment ( 25201988) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 24076602 31604244) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 24390342 30423114)	Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 VMA12 ZDHHC24	64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12
Entrez ID		3460	5376
HPRD ID		00956	03059
Ensembl ID		ENSG00000159128	ENSG00000109099
Uniprot IDs		A8K881 E7EUY1 P38484	A0A2R8Y5L5 A8MU75 Q01453 Q6FH25
PDB IDs		5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Tumor Necrosis Factor Production Type II Interferon-mediated Signaling Pathway Type II Interferon Receptor Binding Oxysterol Binding Macrophage Activation Interferon-mediated Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-23 Production Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Bleb Assembly Cellular Response To Hormone Stimulus Regulation Of Interleukin-23 Production Type III Interferon-mediated Signaling Pathway Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Virus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of MHC Class II Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Nitric Oxide Metabolic Process Regulation Of Intracellular Transport Endomembrane System Positive Regulation Of Monocyte Chemotactic Protein-1 Production Neuroinflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Defense Response To Virus Astrocyte Activation Cellular Response To Virus Positive Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Amyloid-beta Clearance Macrophage Activation Involved In Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Steroid Biosynthetic Process Protein Binding	Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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