IFNGR2 and ENTPD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IFNGR2	ENTPD3
Description		interferon gamma receptor 2	ectonucleoside triphosphate diphosphohydrolase 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Plasma Membrane Membrane
	Molecular Function	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding	Nucleotide Binding Apyrase Activity GDP Phosphatase Activity Protein Binding ATP Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity UDP Phosphatase Activity
	Biological Process	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Defense Response To Virus Type II Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Glutamate Receptor Signaling Pathway	Nucleoside Diphosphate Catabolic Process Nucleoside Triphosphate Catabolic Process
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs	Phosphate bond hydrolysis by NTPDase proteins
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22936669 23128233 28067908) Diverticular disease ( 30177863) Educational attainment ( 25201988) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 24076602 31604244) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 24390342 30423114)	Eosinophil percentage of white cells ( 32888494) Neuroticism ( 29255261)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 VMA12 ZDHHC24	16 interacting genes: ARL13B CREB3L1 ERGIC3 FAM209A FNDC9 GGT6 GPA33 IFNGR2 LEUTX LHFPL5 LMNA MUC1 PTPN5 STX2 SYNE4 TMEM106A
Entrez ID		3460	956
HPRD ID		00956	16014
Ensembl ID		ENSG00000159128	ENSG00000168032
Uniprot IDs		A8K881 E7EUY1 P38484	O75355
PDB IDs		5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Tumor Necrosis Factor Production Type II Interferon-mediated Signaling Pathway Type II Interferon Receptor Binding Oxysterol Binding Macrophage Activation Interferon-mediated Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-23 Production Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Bleb Assembly Cellular Response To Hormone Stimulus Regulation Of Interleukin-23 Production Type III Interferon-mediated Signaling Pathway Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Virus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of MHC Class II Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Nitric Oxide Metabolic Process Regulation Of Intracellular Transport Endomembrane System Positive Regulation Of Monocyte Chemotactic Protein-1 Production Neuroinflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Defense Response To Virus Astrocyte Activation Cellular Response To Virus Positive Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Amyloid-beta Clearance Macrophage Activation Involved In Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Steroid Biosynthetic Process Protein Binding	Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity
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