IFNGR2 and IFNG

Number of citations of the paper that reports this interaction (PubMedID 7673114)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		IFNGR2	IFNG
Description		interferon gamma receptor 2	interferon gamma
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding	Cytokine Activity Type II Interferon Receptor Binding Protein Binding
	Biological Process	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Defense Response To Virus Type II Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Glutamate Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Cytokine Production Adaptive Immune Response Macrophage Activation Involved In Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Macrophage Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-2-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Defense Response To Virus Type II Interferon-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Core Promoter Binding Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG signaling activates MAPKs Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs		Interferon gamma-1b	Olsalazine Glucosamine VIR201 Fontolizumab Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Emapalumab
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	Graft-versus-host disease Allograft rejection
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22936669 23128233 28067908) Diverticular disease ( 30177863) Educational attainment ( 25201988) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 24076602 31604244) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 24390342 30423114)	Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 19122664 20228799 21297633)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 VMA12 ZDHHC24	5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF
Entrez ID		3460	3458
HPRD ID		00956	00957
Ensembl ID		ENSG00000159128	ENSG00000111537
Uniprot IDs		A8K881 E7EUY1 P38484	P01579
PDB IDs		5EH1 6E3K 6E3L	1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Tumor Necrosis Factor Production Type II Interferon-mediated Signaling Pathway Type II Interferon Receptor Binding Oxysterol Binding Macrophage Activation Interferon-mediated Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-23 Production Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Bleb Assembly Cellular Response To Hormone Stimulus Regulation Of Interleukin-23 Production Type III Interferon-mediated Signaling Pathway Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Virus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of MHC Class II Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Nitric Oxide Metabolic Process Regulation Of Intracellular Transport Endomembrane System Positive Regulation Of Monocyte Chemotactic Protein-1 Production Neuroinflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Defense Response To Virus Astrocyte Activation Cellular Response To Virus Positive Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Amyloid-beta Clearance Macrophage Activation Involved In Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Steroid Biosynthetic Process Protein Binding	Type II Interferon Receptor Activity Leukocyte Activation Involved In Inflammatory Response Microglial Cell Activation Macrophage Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Type II Interferon-mediated Signaling Pathway Leukocyte Activation Astrocyte Activation Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amide Metabolic Process Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Defense Response To Virus Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immunoglobulin Production Response To Virus Signal Transduction Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Virus Regulation Of Amide Metabolic Process Regulation Of Immunoglobulin Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Response To External Biotic Stimulus Response To Peptide Response To Cytokine Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Extrinsic Apoptotic Signaling Pathway Tapasin-ERp57 Complex Defense Response Mammary Gland Morphogenesis Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
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