STAT2 and MED14

Number of citations of the paper that reports this interaction (PubMedID 12509459)
62

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		STAT2	MED14
Description		signal transducer and activator of transcription 2	mediator complex subunit 14
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane ISGF3 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mitochondrial Fission	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 20881960 23456168 25429064) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 19169254 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)	Migraine ( 27322543)
Interacting Genes		22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	20 interacting genes: ACTN1 ACTN2 AR CEBPA DCTN1 ESR1 ESR2 FBXL17 HNF4A MED1 MED29 MED9 NECAB2 NR3C1 PARP1 PPARGC1A SREBF1 STAT2 UACA VDR
Entrez ID		6773	9282
HPRD ID		02778	02172
Ensembl ID		ENSG00000170581	ENSG00000180182
Uniprot IDs		A0A494C164 P52630 R9QE65	O60244
PDB IDs		2KA4 6UX2 6WCZ 8T12 8T13	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization Type I Interferon-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Response To Virus Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway P53 Binding Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Cellular Response To Virus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Response To Cytokine Tau Protein Binding Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of RNA Metabolic Process Transcription Coactivator Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Developmental Process Regulation Of Cellular Response To Heat Chromatin Remodeling Regulation Of Metabolic Process	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Sequence-specific DNA Binding Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mammary Gland Branching Involved In Pregnancy Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process DNA-templated Transcription DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Steroid Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Lipid Nucleoplasm Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Response To Hormone RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway DNA Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Chromatin Binding Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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