STAT2 and IWS1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		STAT2	IWS1
Gene Name		signal transducer and activator of transcription 2, 113kDa	IWS1 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Identical Protein Binding	DNA Binding Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Regulation Of Histone H4 Acetylation Regulation Of Histone H3-K36 Trimethylation
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Height ( 20881960 23456168) Psoriasis ( 19169254)
Protein-Protein Interactions		17 interactors: CREBBP CXCR4 EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	7 interactors: CSNK2A1 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1
Entrez ID		6773	55677
HPRD ID		02778	07639
Ensembl ID		ENSG00000170581	ENSG00000163166
Uniprot IDs		P52630 R9QE65	Q96ST2
PDB IDs		2KA4
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response Cellular Response To Organic Substance Response To Cytokine Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Response To Organic Substance Regulation Of Innate Immune Response Regulation Of Signal Transduction JAK-STAT Cascade Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Response To Stress Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Signaling Cell Communication Response To Virus Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Interferon-gamma-mediated Signaling Pathway Interaction With Symbiont Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Autophosphorylation Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cytokine Production Positive Regulation Of Gene Expression Regulation Of Tubulin Deacetylation Cellular Response To Stimulus Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Response To Interferon-gamma Histone Modification Response To Other Organism Transcription, DNA-templated Response To Biotic Stimulus	Viral Process Transcription, DNA-templated RNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Gene Expression Regulation Of Viral Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Viral Process Macromolecule Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Chromosome Organization Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Transcription, RNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Viral Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Histone H3-K27 Methylation Regulation Of MRNA Export From Nucleus Positive Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Export From Nucleus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K27 Methylation MRNA Processing Regulation Of Metabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter MRNA Metabolic Process RNA Processing Positive Regulation Of DNA-templated Transcription, Elongation DNA Repair 7-methylguanosine MRNA Capping
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast	altogether cofactor competent eradication establishment hiv integrase integration investigating latent latently ledgf maintains occupancy p75 participates persistence postintegration provirus reactivation recruit represses reservoir serious silenced silent spt6 steps transcriptionally
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast	altogether cofactor competent eradication establishment hiv integrase integration investigating latent latently ledgf maintains occupancy p75 participates persistence postintegration provirus reactivation recruit represses reservoir serious silenced silent spt6 steps transcriptionally
Tagcloud (Intersection) ?