IFNA2 and IFNAR2

Number of citations of the paper that reports this interaction (PMID 10339405)
22

Data Source:
HPRD (in vitro)

		IFNA2	IFNAR2
Gene Name		interferon, alpha 2	interferon (alpha, beta and omega) receptor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding
	Biological Process	Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Innate Immune Response Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		2 interactors: IFNAR1 IFNAR2	14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3440	3455
HPRD ID		00950	03850
Ensembl ID		ENSG00000188379	ENSG00000159110
Uniprot IDs		P01563 Q6DJX8	P48551 Q9BUA0
PDB IDs		1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Type I Interferon Biosynthetic Process Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Type I Interferon Production Response To Interferon-alpha Regulation Of Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Cytokine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Cytokine Metabolic Process Positive Regulation Of Interleukin-1 Production Immune Response Regulation Of Immune System Process Defense Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interferon-gamma Production Response To External Stimulus Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Response To Organic Substance Cytokine Production Defense Response To Virus Regulation Of Signal Transduction Positive Regulation Of Protein Secretion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Stress T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion	Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels
Tagcloud ?		2d antiviral attractive circular cleaved compromised dichroism fermenter hairy heteronuclear historically industry interferon leaving leukocytes makes nibsc pbl pharmaceutical protocols purification scheme science sumo tag tertiary ulp1 ultracentrifugation yields	aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1
Tagcloud (Difference) ?		2d antiviral attractive circular cleaved compromised dichroism fermenter hairy heteronuclear historically industry interferon leaving leukocytes makes nibsc pbl pharmaceutical protocols purification scheme science sumo tag tertiary ulp1 ultracentrifugation yields	aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1
Tagcloud (Intersection) ?