IFNA2

Gene Name		interferon, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process	Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Innate Immune Response Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: IFNAR1 IFNAR2
Entrez ID		3440
HPRD ID		00950
Ensembl ID		ENSG00000188379
Uniprot IDs		P01563 Q6DJX8
PDB IDs		1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Type I Interferon Biosynthetic Process Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Type I Interferon Production Response To Interferon-alpha Regulation Of Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Cytokine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Cytokine Metabolic Process Positive Regulation Of Interleukin-1 Production Immune Response Regulation Of Immune System Process Defense Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interferon-gamma Production Response To External Stimulus Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Response To Organic Substance Cytokine Production Defense Response To Virus Regulation Of Signal Transduction Positive Regulation Of Protein Secretion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Stress T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion
Tagcloud ?		2d antiviral attractive circular cleaved compromised dichroism fermenter hairy heteronuclear historically industry interferon leaving leukocytes makes nibsc pbl pharmaceutical protocols purification scheme science sumo tag tertiary ulp1 ultracentrifugation yields