JMJD6 and NAA50

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		JMJD6	NAA50
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	N-alpha-acetyltransferase 50, NatE catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Nucleus Nucleolus Cytoplasm Cytosol NatA Complex Extracellular Exosome
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-lysine-acetyltransferase Activity Protein N-terminal-methionine Acetyltransferase Activity
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly	Chromatin Remodeling N-terminal Protein Amino Acid Acetylation Mitotic Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Post-translational Protein Modification Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Prostate cancer ( 23535732)
Interacting Genes		30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	6 interacting genes: BHLHE40 CEBPA JMJD6 NAA10 NAA15 OTX2
Entrez ID		23210	80218
HPRD ID		05371	14350
Ensembl ID		ENSG00000070495	ENSG00000121579
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1	E7EQ69 Q9GZZ1
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	2OB0 2PSW 3TFY 4X5K 6PPL 6PW9 6WF3 6WF5 6WFG 6WFK 6WFN 6WFO 9F1B 9F1C 9F1D
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus	NatA Complex Lung Development N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity Protein Acetylation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Ribosome Binding Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Response To Vitamin B2 C/EBP Complex Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity CHOP-C/EBP Complex Protein N-terminal-serine Acetyltransferase Activity Negative Regulation Of Protein Homooligomerization Ciliary Inversin Compartment White Fat Cell Proliferation Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Maintenance Of Animal Organ Identity DNA-binding Transcription Factor Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion MRF Binding Kidney Development Determination Of Pancreatic Left/right Asymmetry Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-N-terminal Amino-acid Acetyltransferase Activity Recognition Of Apoptotic Cell Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Response To Phenylpropanoid Regulation Of RNA Biosynthetic Process Fat Cell Proliferation Eukaryotic Initiation Factor 4E Binding Anatomical Structure Formation Involved In Morphogenesis
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