JMJD6

Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways		HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Novel Interacting Genes		1 novel interacting genes: BAG5
Interacting Genes		30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		23210
HPRD ID		05371
Ensembl ID		ENSG00000070495
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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