JMJD6 and CENPL

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		JMJD6	CENPL
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	centromere protein L
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity	Protein Binding
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly	Chromosome Segregation
Pathways		HDMs demethylate histones Protein hydroxylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	2 interacting genes: FAM9B JMJD6
Entrez ID		23210	91687
HPRD ID		05371	15909
Ensembl ID		ENSG00000070495	ENSG00000120334
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1	Q8N0S6
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus	Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Recognition Of Apoptotic Cell Oxidative Demethylation Peptidyl-lysine Hydroxylation Demethylation Transcription Regulator Activator Activity Phagocytosis, Recognition Protein Hydroxylation Histone Demethylase Activity Cell Development Apoptotic Cell Clearance Synaptonemal Complex Erythrocyte Development Sprouting Angiogenesis T Cell Differentiation In Thymus Single-stranded RNA Binding Macrophage Activation Myeloid Cell Development Dioxygenase Activity Retina Development In Camera-type Eye
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