JMJD6 and NHP2

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		JMJD6	NHP2
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	NHP2 ribonucleoprotein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding U3 SnoRNA Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly	SnoRNA Guided RRNA Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Ribosome Biogenesis Telomerase RNA Localization To Cajal Body
Pathways		HDMs demethylate histones Protein hydroxylation	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Platelet count ( 29403010)
Interacting Genes		30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	10 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOS1AP PRNP RSPH1 UBE2I UTP23
Entrez ID		23210	55651
HPRD ID		05371	07570
Ensembl ID		ENSG00000070495	ENSG00000145912
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1	J3QSY4 Q9NX24
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Transmembrane Transporter Binding Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Cytosol Neuromuscular Junction Development Regulation Of Membrane Repolarization Receptor Metabolic Process Regulation Of T Cell Receptor Signaling Pathway Muscle Cell Fate Specification Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Type 8 Metabotropic Glutamate Receptor Binding SUMO Conjugating Enzyme Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Component Assembly Signaling Adaptor Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Regulation Of Membrane Potential Phosphothreonine Residue Binding Negative Regulation Of Monoatomic Ion Transport Regulation Of Dendrite Development RING-like Zinc Finger Domain Binding Linear Polyubiquitin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Homooligomerization
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