CD209 and CLEC4M

Number of citations of the paper that reports this interaction (PubMedID 11384997)
0

Data Source:
HPRD (in vitro)

		CD209	CLEC4M
Description		CD209 molecule	C-type lectin domain family 4 member M
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Host Cell	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Host Cell
	Molecular Function	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding ICAM-3 Receptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Endocytosis Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-cell Recognition Virion Attachment To Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of T Cell Proliferation Innate Immune Response Symbiont Entry Into Host Cell Peptide Antigen Transport Intracellular Transport Of Virus B Cell Adhesion Positive Regulation Of Viral Life Cycle	Adaptive Immune Response Immune System Process Endocytosis Immune Response Leukocyte Cell-cell Adhesion Cell-cell Recognition Virion Attachment To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Innate Immune Response Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Peptide Antigen Transport Intracellular Transport Of Virus
Pathways		CD209 (DC-SIGN) signaling Butyrophilin (BTN) family interactions RSV-host interactions	RSV-host interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Lipoprotein (a) levels ( 33730874) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) vWF levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CEACAM1 CLEC4M CLU CRYAA ICAM2 ICAM3 IFT20 ITGAM TCEAL8 VAC14	6 interacting genes: CD209 ICAM3 IFT20 ITGAM PLPP6 SNCA
Entrez ID		30835	10332
HPRD ID		05241	12060
Ensembl ID		ENSG00000090659	ENSG00000104938
Uniprot IDs		B2R907 B4E2A8 M0R0P0 Q9NNX6 X6RB12	A0A7P0MMK7 Q9H2X3
PDB IDs		1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6 6GHV 7NL6 7NL7 9EMQ 9EMR 9EMS	1K9J 1SL6 1XAR 1XPH 3JQH 8RCY
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Endocytosis Cell Adhesion Amyloid-beta Clearance Integrin Binding Receptor-mediated Endocytosis Microglial Cell Activation Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Import Into Cell Signaling Receptor Activity Macrophage Activation Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction PAS Complex Tertiary Granule Membrane Microvillus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Negative Regulation Of Hepatocyte Proliferation Regulation Of Transport Regulation Of Leukocyte Mediated Cytotoxicity Specific Granule Membrane Integrin-mediated Signaling Pathway Cell Periphery Amyloid-beta Binding Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Maintenance Immune Complex Clearance Integrin AlphaM-beta2 Complex Positive Regulation Of Neutrophil Degranulation Response To Curcumin Vertebrate Eye-specific Patterning ICAM-3 Receptor Activity Peptide Antigen Transport Kinociliary Basal Body Opsin Transport Intraciliary Transport Particle Unfolded Protein Binding Insulin Catabolic Process Regulation Of Regulated Secretory Pathway Regulation Of Receptor-mediated Endocytosis Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Complement-mediated Synapse Pruning Opsin Binding	Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Endocytosis Import Into Cell Regulation Of Dopamine Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Vesicle-mediated Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Macrophage Activation Positive Regulation Of Exocytosis Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission B Cell Adhesion Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Cell-cell Adhesion Response To External Biotic Stimulus Integrin AlphaM-beta2 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Opsin Transport Intraciliary Transport Particle Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Neutrophil Degranulation Response To Curcumin Vertebrate Eye-specific Patterning Myeloid Leukocyte Activation Regulation Of Immune System Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Cell Activation Negative Regulation Of Chaperone-mediated Autophagy Peptide Antigen Transport Kinociliary Basal Body Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Integrin Binding Positive Regulation Of Microglial Cell Mediated Cytotoxicity Complement-mediated Synapse Pruning Regulation Of Serotonin Uptake Opsin Binding Receptor-mediated Endocytosis
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