CD209 and CLU

Number of citations of the paper that reports this interaction (PMID 22013110)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CD209	CLU
Gene Name		CD209 molecule	clusterin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Protein Binding Mannose Binding Carbohydrate Binding Peptide Antigen Binding Virion Binding Metal Ion Binding	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Endocytosis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-cell Recognition Modulation By Virus Of Host Morphology Or Physiology Virion Attachment To Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Regulation Of T Cell Proliferation Innate Immune Response Peptide Antigen Transport Intracellular Transport Of Virus	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		7 interactors: CEACAM1 CLEC4M CLU ICAM2 ICAM3 ITGAM VAC14	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		30835	1191
HPRD ID		05241	01706
Ensembl ID		ENSG00000090659	ENSG00000120885
Uniprot IDs		B2R907 B4E2A8 M0QZG5 M0R0P0 Q9NNX6	P10909
PDB IDs		1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Regulation Of Immune System Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Glial Cell Development Regulation Of Body Fluid Levels Wound Healing Leukocyte Proliferation Integrin-mediated Signaling Pathway Microglia Development Positive Regulation Of Neurofibrillary Tangle Assembly Response To Wounding Peptide Antigen Transport Central Nervous System Myelin Maintenance Glial Cell Differentiation Innate Immune Response Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Ectodermal Cell Differentiation Leukocyte Migration Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Gliogenesis Virion Attachment To Host Cell Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Adhesion Of Symbiont To Host Negative Regulation Of Beta-amyloid Formation Leukocyte Cell-cell Adhesion Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Glial Cell Proliferation Response To Misfolded Protein Immune Response Regulation Of Beta-amyloid Formation Leukocyte Migration Involved In Inflammatory Response Defense Response Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelination	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		accreta assure basalis cd205 cd25 cd56 cd68 cd83 cytokeratin dec205 decidua evt extravillous foxp3 immature increta infertility intrauterine iug mann maturated miscarriage originates parietalis preeclampsia treg trophoblast whitney	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		accreta assure basalis cd205 cd25 cd56 cd68 cd83 cytokeratin dec205 decidua evt extravillous foxp3 immature increta infertility intrauterine iug mann maturated miscarriage originates parietalis preeclampsia treg trophoblast whitney	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
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