ICA1 and MBD3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ICA1	MBD3
Gene Name		islet cell autoantigen 1, 69kDa	methyl-CpG binding domain protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Cell Junction Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex
	Molecular Function	Molecular_function Protein Domain Specific Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Neurotransmitter Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B	28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277
Entrez ID		3382	53615
HPRD ID		00971	04653
Ensembl ID		ENSG00000003147	ENSG00000071655
Uniprot IDs		Q05084 Q96HG3	O95983
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Ras Protein Signal Transduction Peptidyl-lysine Modification Methylation-dependent Chromatin Silencing Organelle Organization Protein Transport Establishment Of Protein Localization Intracellular Transport Histone Modification Protein Localization Establishment Of Localization In Cell Chromatin Modification Small GTPase Mediated Signal Transduction Chromatin Silencing	ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding
Tagcloud ?		6x10 7x10 aicda bank1 card8 ccl11 eotaxin fisher formations gc germinal ikbke il17a keratoconjunctivitis lacrimal minor norwegian pkn1 pss rheumatic salivary sicca sjogren snps suggestive suggestively swedish tank xerostomia	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Difference) ?		6x10 7x10 aicda bank1 card8 ccl11 eotaxin fisher formations gc germinal ikbke il17a keratoconjunctivitis lacrimal minor norwegian pkn1 pss rheumatic salivary sicca sjogren snps suggestive suggestively swedish tank xerostomia	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Intersection) ?