ICA1 and RAB2A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ICA1	RAB2A
Description		islet cell autoantigen 1	RAB2A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Neurotransmitter Transport Regulation Of Secretion Membrane Bending	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion
Pathways			Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) Intraocular pressure ( 23836780) Metabolite levels (Pyroglutamine) ( 23934736) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 28714469)	Aspartate aminotransferase levels ( 33547301) Autoimmune thyroid disease ( 32581359) Estimated glomerular filtration rate ( 31152163) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Systemic sclerosis ( 31672989) Total cholesterol levels ( 29083408)
Interacting Genes		9 interacting genes: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B SHANK3 SNCA TSC1	29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7
Entrez ID		3382	5862
HPRD ID		00971	01539
Ensembl ID		ENSG00000003147	ENSG00000104388
Uniprot IDs		A0A024RA29 Q05084	P61019
PDB IDs			1Z0A
Enriched GO Terms of Interacting Partners?		Autophagosome Membrane Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Adult Behavior Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Synapse Organization Memory T Cell Differentiation Acrosomal Vesicle Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Adult Locomotory Behavior Transporter Regulator Activity Regulation Of Norepinephrine Uptake Regulation Of Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Cell Junction Organization Regulation Of Cell Size TSC1-TSC2 Complex Associative Learning DNA Replication-dependent Chromatin Disassembly Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Golgi Organization Vesicle-mediated Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Synaptic Receptor Adaptor Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Synaptic Transmission ATPase Inhibitor Activity Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Macroautophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Learning Response To Bisphenol A
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