ICA1

Name	islet cell autoantigen 1
Structure	No pdb structure
Interactors	9 interactors: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B SHANK3 SNCA TSC1
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity
	Biological Process	Neurotransmitter Transport Regulation Of Secretion Membrane Bending
GWAS	Cognitive function ( 24684796 ) Intraocular pressure ( 23836780 ) Metabolite levels (Pyroglutamine) ( 23934736 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Systemic lupus erythematosus ( 28714469 )
Entrez ID	3382
HPRD ID	00971
Ensembl ID	ENSG00000003147
Uniprot IDs	A0A024RA29 Q05084
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Autophagosome Membrane Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Adult Behavior Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Synapse Organization Memory T Cell Differentiation Acrosomal Vesicle Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Adult Locomotory Behavior Transporter Regulator Activity Regulation Of Norepinephrine Uptake Regulation Of Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Cell Junction Organization Regulation Of Cell Size TSC1-TSC2 Complex Associative Learning DNA Replication-dependent Chromatin Disassembly Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Golgi Organization Vesicle-mediated Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Synaptic Receptor Adaptor Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Synaptic Transmission ATPase Inhibitor Activity Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Macroautophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Learning Response To Bisphenol A