ICA1 and RAB2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ICA1	RAB2B
Description		islet cell autoantigen 1	RAB2B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Neurotransmitter Transport Regulation Of Secretion Membrane Bending	Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Exocytosis Defense Response To Virus
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) Intraocular pressure ( 23836780) Metabolite levels (Pyroglutamine) ( 23934736) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 28714469)	Height ( 31562340)
Interacting Genes		9 interacting genes: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B SHANK3 SNCA TSC1	20 interacting genes: ADAMTSL4 APP BLZF1 CRK FAM114A1 FAM114A2 GARIN4 GARIN6 GOLGA2 ICA1 MEOX2 NOP2 SGSM2 SMAD1 SMAD4 SRSF11 STAMBPL1 TBX19 TXNDC11 VRTN
Entrez ID		3382	84932
HPRD ID		00971	06312
Ensembl ID		ENSG00000003147	ENSG00000129472
Uniprot IDs		A0A024RA29 Q05084	B4DUD4 Q8WUD1
PDB IDs			2A5J
Enriched GO Terms of Interacting Partners?		Autophagosome Membrane Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Adult Behavior Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Synapse Organization Memory T Cell Differentiation Acrosomal Vesicle Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Adult Locomotory Behavior Transporter Regulator Activity Regulation Of Norepinephrine Uptake Regulation Of Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Cell Junction Organization Regulation Of Cell Size TSC1-TSC2 Complex Associative Learning DNA Replication-dependent Chromatin Disassembly Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Golgi Organization Vesicle-mediated Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Synaptic Receptor Adaptor Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Synaptic Transmission ATPase Inhibitor Activity Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Macroautophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Learning Response To Bisphenol A	Heteromeric SMAD Protein Complex Embryonic Pattern Specification SMAD Protein Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Response To Yeast I-SMAD Binding Cardiac Conduction System Development Cellular Response To Growth Factor Stimulus Golgi Organization SMAD Protein Signal Transduction
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