SYT5 and RAB1A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SYT5	RAB1A
Gene Name		synaptotagmin V	RAB1A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Golgi Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Melanosome Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Energy Reserve Metabolic Process Synaptic Transmission Calcium Ion-dependent Exocytosis Small Molecule Metabolic Process Regulation Of Insulin Secretion	Autophagic Vacuole Assembly Mitotic Cell Cycle Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Rab Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cilium Assembly Defense Response To Bacterium Vesicle Transport Along Microtubule Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process
Pathways		Integration of energy metabolism Regulation of insulin secretion	Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: NRXN1 POLR2E RAB1A SYT3	28 interactors: ADCK1 CAPNS1 CDKN1A CHM CHML CREB1 FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 OCRL PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RABIF RFK RUSC2 SLC16A8 SYT5 TBC1D17 USO1 ZNF593
Entrez ID		6861	5861
HPRD ID		02870	01538
Ensembl ID			ENSG00000138069
Uniprot IDs		O00445 Q4FD32	B7Z8M7 P62820 Q5U0I6
PDB IDs			2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS
Enriched GO Terms of Interacting Partners?		Secretion By Cell Secretion Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Vesicle Localization Gephyrin Clustering Synaptic Vesicle Clustering Interleukin-8 Production Neuronal Signal Transduction N-methyl-D-aspartate Receptor Clustering Vocal Learning Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Synapse Maturation Regulation Of Grooming Behavior Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Cargo Loading Into Vesicle Receptor Localization To Synapse Presynaptic Membrane Organization Auditory Behavior Cell Development Growth Hormone Secretion Organelle Localization Cerebellar Granule Cell Differentiation Establishment Of Localization In Cell Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Positive Regulation Of Synapse Maturation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Glycoprotein Metabolic Process Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Viral Process Response To Auditory Stimulus Regulation Of Synapse Maturation Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Vesicle Fusion Membrane Assembly Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic COPII-coated Vesicle Budding Cerebellar Granular Layer Development	Protein Geranylgeranylation Protein Prenylation Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Mitotic Cell Cycle Regulation Of GTPase Activity Membrane Fusion Positive Regulation Of Metabolic Process Protein Transport Establishment Of Protein Localization Visual Perception Sensory Perception Of Light Stimulus Slow Endocytic Recycling Riboflavin Biosynthetic Process FMN Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Membrane Organization Positive Regulation Of Microtubule Plus-end Binding Golgi Vesicle Docking Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cell Cycle Positive Regulation Of Cell Cycle Arrest Cellular Process Positive Regulation Of NAD(P)H Oxidase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Apoptotic Process Protein Localization Vesicle-mediated Transport Programmed Cell Death Signal Transduction In Response To DNA Damage Establishment Of Localization In Cell Mitotic DNA Damage Checkpoint Cell Death Death Intestinal Epithelial Cell Maturation Riboflavin Metabolic Process Regulation Of Cell Cycle Arrest Intracellular Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint
Tagcloud ?		activities altered animals app avp biological changed condition differentially enantiomers entire hypothalamic igf2 igfbp2 influences inhalation linalool microarray monitored nervous possess previous profile r rats relate restrained sst stressed	added become broadly characterises eevs enveloped exploits facilitating golgi growing gtpase highlighting ievs immunofluorescence imvs list maintenance mature numerous optimal proviral refined replication require stranded vaccinia vacv virions wrapping
Tagcloud (Difference) ?		activities altered animals app avp biological changed condition differentially enantiomers entire hypothalamic igf2 igfbp2 influences inhalation linalool microarray monitored nervous possess previous profile r rats relate restrained sst stressed	added become broadly characterises eevs enveloped exploits facilitating golgi growing gtpase highlighting ievs immunofluorescence imvs list maintenance mature numerous optimal proviral refined replication require stranded vaccinia vacv virions wrapping
Tagcloud (Intersection) ?