SYT5 and RAB1A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SYT5	RAB1A
Description		synaptotagmin 5	RAB1A, member RAS oncogene family
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection	Golgi Membrane Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Melanosome Extracellular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Cadherin Binding Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Exocytosis	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Protein Transport Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Positive Regulation Of Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Vesicle Transport Along Microtubule Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process
Pathways		Regulation of insulin secretion	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		7 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SHANK3 SYT3	32 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D FNDC3B FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 MTOR OCRL PLK1 PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RFK RUSC2 SLC16A8 SNCA SSX2IP SYT5 TBC1D17 USO1 ZNF593
Entrez ID		6861	5861
HPRD ID		02870	01538
Ensembl ID		ENSG00000129990	ENSG00000138069
Uniprot IDs		O00445 Q4FD32	B7Z8M7 P62820 Q5U0I6
PDB IDs		5H4Y 5H4Z	2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS 7EQ2 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Guanylate Kinase-associated Protein Clustering NMDA Glutamate Receptor Clustering Vocal Learning Observational Learning Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Mechanosensory Behavior Vocalization Behavior Signal Release Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Nervous System Development Transport Vesicle Membrane Receptor Clustering Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Epiboly Involved In Gastrulation With Mouth Forming Second Plasma Membrane Bounded Cell Projection Organization Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Social Behavior Synapse Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Secretion By Cell Regulation Of Nervous System Development Cell Projection Organization Melanosome Protein Complex Involved In Cell-cell Adhesion Synapse Assembly Positive Regulation Of Cellular Component Organization Neuron Projection Development Neuromuscular Process Fasciculation Of Sensory Neuron Axon Secretion Vesicle Localization Regulation Of Nervous System Process Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Central Nervous System Neuron Differentiation Negative Regulation Of Filopodium Assembly Synaptic Receptor Adaptor Activity Positive Regulation Of Developmental Process	Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Small GTPase Binding Golgi Organization Protein Prenylation Vesicle-mediated Transport Organelle Organization Golgi Vesicle Transport Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Prenyltransferase Activity Cytoplasm Organelle Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Protein Localization To Cytoskeleton Centrosome Cycle Cis-Golgi Network Establishment Of Localization In Cell Prenyltransferase Activity Protein Destabilization Cytoplasmic Vesicle Protein Localization To Cilium Spindle Organization Cytosol Ciliary Basal Body Cadherin Binding Intracellular Transport Behavioral Response To Cocaine Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization Cell Projection Assembly Spindle Assembly Protein Serine/threonine Kinase Binding Protein Localization To Organelle GTPase Activator Activity Chemotaxis To Arachidonate Regulation Of Protein-containing Complex Assembly Microtubule Nucleation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cilium Assembly Cellular Component Assembly Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Organelle Assembly
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