SYT5 and POLR2E

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SYT5	POLR2E
Gene Name		synaptotagmin V	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	Transporter Activity Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase I Activity RNA Polymerase II Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Energy Reserve Metabolic Process Synaptic Transmission Calcium Ion-dependent Exocytosis Small Molecule Metabolic Process Regulation Of Insulin Secretion	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription RNA Splicing Gene Expression Viral Process Positive Regulation Of Type I Interferon Production PiRNA Metabolic Process Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		Integration of energy metabolism Regulation of insulin secretion	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation Abortive elongation of HIV-1 transcript in the absence of Tat RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Regulatory RNA pathways Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER Influenza Life Cycle RNA Polymerase III Transcription Termination HIV elongation arrest and recovery NoRC negatively regulates rRNA expression Influenza Viral RNA Transcription and Replication RNA Polymerase III Chain Elongation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation Transcription of the HIV genome Nucleotide Excision Repair PIWI-interacting RNA (piRNA) biogenesis mRNA Splicing RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Innate Immune System RNA Polymerase III Transcription Initiation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Pausing and recovery of HIV elongation Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: NRXN1 POLR2E RAB1A SYT3	25 interactors: CHGB FKBP14 FOS GTF2B GTF2F2 HSP90B1 IKBKG ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 URI1 ZSCAN1
Entrez ID		6861	5434
HPRD ID		02870	15946
Ensembl ID
Uniprot IDs		O00445 Q4FD32	B4DJ89 P19388
PDB IDs
Enriched GO Terms of Interacting Partners?		Secretion By Cell Secretion Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Vesicle Localization Gephyrin Clustering Synaptic Vesicle Clustering Interleukin-8 Production Neuronal Signal Transduction N-methyl-D-aspartate Receptor Clustering Vocal Learning Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Synapse Maturation Regulation Of Grooming Behavior Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Cargo Loading Into Vesicle Receptor Localization To Synapse Presynaptic Membrane Organization Auditory Behavior Cell Development Growth Hormone Secretion Organelle Localization Cerebellar Granule Cell Differentiation Establishment Of Localization In Cell Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Positive Regulation Of Synapse Maturation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Glycoprotein Metabolic Process Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Viral Process Response To Auditory Stimulus Regulation Of Synapse Maturation Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Vesicle Fusion Membrane Assembly Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic COPII-coated Vesicle Budding Cerebellar Granular Layer Development	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Viral Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Positive Regulation Of Viral Transcription Regulation Of Viral Process PiRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Viral Transcription Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Nitrogen Compound Metabolic Process Nucleotide-excision Repair RNA Splicing Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Stem Cell Maintenance RNA Biosynthetic Process Regulation Of Gene Expression MRNA Processing Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cellular Response To Stress Gene Expression MRNA Metabolic Process Regulation Of Metabolic Process RNA Processing Stem Cell Development Stem Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Cellular Macromolecule Biosynthetic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process
Tagcloud ?		activities altered animals app avp biological changed condition differentially enantiomers entire hypothalamic igf2 igfbp2 influences inhalation linalool microarray monitored nervous possess previous profile r rats relate restrained sst stressed	actinomycin amanitin binds crm1 cytoplasmic demonstrating elusive entire export exported exportin fact interactor interactors leptomycin modification pdrg1 prefoldin proteomic r2tp repressor rpb5 shuttling spectrometry stabilized stall unconventional uri
Tagcloud (Difference) ?		activities altered animals app avp biological changed condition differentially enantiomers hypothalamic igf2 igfbp2 influences inhalation linalool microarray monitored nervous possess previous profile r rats relate restrained sst stressed	actinomycin amanitin binds crm1 cytoplasmic demonstrating elusive export exported exportin fact interactor interactors leptomycin modification pdrg1 prefoldin proteomic r2tp repressor rpb5 shuttling spectrometry stabilized stall unconventional uri
Tagcloud (Intersection) ?		entire