SYT5 and POLR2E

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SYT5	POLR2E
Description		synaptotagmin 5	RNA polymerase II, I and III subunit E
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Exocytosis	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Protein Stabilization
Pathways		Regulation of insulin secretion	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)
Interacting Genes		7 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SHANK3 SYT3	29 interacting genes: CHGB FKBP14 FOS GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 UBE2D1 UBE2D4 URI1 ZSCAN1
Entrez ID		6861	5434
HPRD ID		02870	15946
Ensembl ID		ENSG00000129990	ENSG00000099817
Uniprot IDs		O00445 Q4FD32	B4DJ89 E5KT65 P19388
PDB IDs		5H4Y 5H4Z	5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Guanylate Kinase-associated Protein Clustering NMDA Glutamate Receptor Clustering Vocal Learning Observational Learning Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Mechanosensory Behavior Vocalization Behavior Signal Release Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Nervous System Development Transport Vesicle Membrane Receptor Clustering Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Epiboly Involved In Gastrulation With Mouth Forming Second Plasma Membrane Bounded Cell Projection Organization Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Social Behavior Synapse Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Secretion By Cell Regulation Of Nervous System Development Cell Projection Organization Melanosome Protein Complex Involved In Cell-cell Adhesion Synapse Assembly Positive Regulation Of Cellular Component Organization Neuron Projection Development Neuromuscular Process Fasciculation Of Sensory Neuron Axon Secretion Vesicle Localization Regulation Of Nervous System Process Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Central Nervous System Neuron Differentiation Negative Regulation Of Filopodium Assembly Synaptic Receptor Adaptor Activity Positive Regulation Of Developmental Process	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Transcription By RNA Polymerase II DNA-templated Transcription DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleus Protein K63-linked Ubiquitination Nucleoplasm Innate Immune Response Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Nucleic Acid Metabolic Process Protein K48-linked Ubiquitination Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Transcription Initiation At RNA Polymerase II Promoter Response To External Biotic Stimulus Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Response To Other Organism TRNA Transcription By RNA Polymerase III TRNA Transcription Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding DNA-templated Transcription Initiation Transcription By RNA Polymerase I Regulation Of Primary Metabolic Process Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Protein Modification Process Defense Response Translation Initiation Factor Binding Regulation Of Gene Expression SMAD Protein Signal Transduction Transferase Activity Regulation Of Macromolecule Biosynthetic Process Medium-term Memory Cellular Response To Prolactin
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