SUB1 and OTUD5

Number of citations of the paper that reports this interaction (PubMedID 30508113)
53

Data Source:
BioGRID (pull down)

		SUB1	OTUD5
Description		SUB1 regulator of transcription	OTU deubiquitinase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Extracellular Exosome	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	RNA Polymerase II Promoter Clearance Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Cytokine Production Proteolysis Neural Crest Cell Differentiation Protein Deubiquitination Cell Differentiation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Regulation Of Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways			Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		24 interacting genes: ADAP1 APP CBX5 CEBPA CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 OTUD5 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST RNF10 SDCBP SP1 TAF1 TBP TP53	12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5
Entrez ID		10923	55593
HPRD ID		02737	06488
Ensembl ID		ENSG00000113387	ENSG00000068308
Uniprot IDs		P53999 Q6IBA2	Q96G74
PDB IDs		1PCF 2C62 2PHE 4USG 6YCS 7E4W	3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process STAT Family Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Chromatin Organization Rhythmic Process Euchromatin MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Xenobiotic Stimulus RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Radiation DNA-binding Transcription Factor Binding	RNA Polymerase II, Core Complex Ubiquitin Protein Ligase Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex DNA-templated Transcription 5'-3' RNA Polymerase Activity MRNA Transcription RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Protein Tag Activity Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus DNA Binding Nucleoplasm Macromolecule Biosynthetic Process RNA Binding MRNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Growth Cone Leading Edge Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription By RNA Polymerase II Interferon-mediated Signaling Pathway Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Heterochromatin Boundary Formation Regulation Of DNA-templated Transcription Initiation Regulation Of Proteolysis Nucleotidyltransferase Activity Ribonucleoside Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Site Of Double-strand Break Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Circadian Rhythm Positive Regulation Of Thymocyte Apoptotic Process
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