SUB1 and HNF4A

Number of citations of the paper that reports this interaction (PMID 11741883)
4

Data Source:
HPRD (in vitro, in vivo)

		SUB1	HNF4A
Gene Name		SUB1 homolog (S. cerevisiae)	hepatocyte nuclear factor 4, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Nucleolus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Signal Transduction	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Glucose Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Positive Regulation Of Cholesterol Homeostasis
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			C-reactive protein ( 21300955 22939635) Cholesterol, total ( 20686565) HDL cholesterol ( 19060906 20686565) Type 2 diabetes ( 21874001 22158537) Ulcerative colitis ( 19915572 23128233)
Protein-Protein Interactions		19 interactors: ADAP1 APP CBX5 CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST SP1 TAF1 TBP	62 interactors: ANP32B COPS5 CREBBP ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HNF1A MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 SUMO1 SUMO2 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		10923	3172
HPRD ID		02737	02612
Ensembl ID		ENSG00000113387	ENSG00000101076
Uniprot IDs		P53999 Q6IBA2	F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1PCF 2C62 2PHE	1PZL 3CBB 3FS1 4B7W 4IQR
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of Viral Process Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Interaction With Symbiont Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Stress MRNA Processing Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Cellular Process MRNA Metabolic Process Nucleotide-excision Repair	Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Response To Hormone Stem Cell Maintenance Cellular Response To Organic Substance
Tagcloud ?		biosynthetic choline coactivators demethylation dot1 ecm5 gcn5 gis1 icre ino2 ino4 inositol jhd1 jhd2 lys36 med15 med18 med19 med2 med3 mediator methyltransferase modify phospholipid recruit rph1 set1 set2 snf1	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Difference) ?		biosynthetic choline coactivators demethylation dot1 ecm5 gcn5 gis1 icre ino2 ino4 inositol jhd1 jhd2 lys36 med15 med18 med19 med2 med3 mediator methyltransferase modify phospholipid recruit rph1 set1 set2 snf1	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Intersection) ?