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BIRC2 and E2F1
Number of citations of the paper that reports this interaction (PubMedID
30359437
)
55
Data Source:
BioGRID
(pull down, pull down)
BIRC2
E2F1
Description
baculoviral IAP repeat containing 2
E2F transcription factor 1
Image
GO Annotations
Cellular Component
XY Body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
CD40 Receptor Complex
Nuclear Chromosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
FBXO Family Protein Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
Response To Hypoxia
Placenta Development
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of RIG-I Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Response To Ethanol
Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Regulation Of Inflammatory Response
Response To CAMP
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Necroptotic Process
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Positive Regulation Of Protein Polyubiquitination
Response To Bleomycin
Regulation Of Reactive Oxygen Species Metabolic Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Regulation Of Cell Cycle
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
80 interacting genes:
ABHD17A
BIRC5
BIRC6
BLK
BMX
BOLA1
BOLA2
BOLA2B
CASP3
CASP7
CASP9
CBLC
CD40
CDC42
CSE1L
CTBP2
DIABLO
DZIP3
E2F1
EAF2
EIF4E
EXOSC5
FBXO7
FTCD
GAS1
GCC1
GFAP
GLMN
GSPT1
HSP90B1
HTRA2
IGF2BP1
IKBKE
IKBKG
JUP
KDM1A
LNX1
LTBR
MAD1L1
MAGEA11
MAP3K2
MAP3K3
MAP3K5
NMB
NXF1
OTUB1
PACS2
PCSK9
PFN2
PPM1K
RAC1
RAF1
RFC5
RHOA
RIPK2
RIPK3
RIPK4
RNF181
RUNX1T1
TCAF1
TNF
TRADD
TRAF1
TRAF2
TRIM34
TSG101
TSGA10
TUFT1
UBB
UBC
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2J1
UBE2N
UBE2Q2
UBE2S
UBE2V1
UBE2W
83 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CCNF
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB1
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
SZRD1P1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
329
1869
HPRD ID
03419
01806
Ensembl ID
ENSG00000110330
ENSG00000101412
Uniprot IDs
Q13490
Q01094
Q9BSD8
PDB IDs
1QBH
2L9M
3D9T
3D9U
3M1D
3MUP
3OZ1
3T6P
3UW4
4EB9
4HY4
4HY5
4KMN
4LGE
4LGU
4MTI
4MU7
5M6N
6EXW
6HPR
6W74
6W7O
6W8I
7QGJ
7TRL
7TRM
8DSF
8DSO
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
9CB3
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Cell Death
Apoptotic Process
Programmed Cell Death
Protein Modification Process
Post-translational Protein Modification
Protein Ubiquitination
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Protein Metabolic Process
Regulation Of Apoptotic Process
Macromolecule Catabolic Process
Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Polyubiquitination
Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Modification Process
Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Programmed Cell Death
Transferase Activity
Protein-containing Complex
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Apoptotic Signaling Pathway
Regulation Of Protein Modification Process
Cytoplasm
Proteolysis
Thioesterase Binding
Proteolysis Involved In Protein Catabolic Process
Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Intrinsic Apoptotic Signaling Pathway
CD40 Receptor Complex
Nucleotide Binding
Regulation Of Apoptotic Signaling Pathway
Regulation Of Neuron Apoptotic Process
Modification-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Chromatin Organization
DNA Damage Response
Chromatin Remodeling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Repair
G1/S Transition Of Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle G1/S Phase Transition
Chromatin
Cellular Response To Stress
Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Protein Localization To Site Of Double-strand Break
Positive Regulation Of DNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Programmed Cell Death
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