BIRC2 and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 23453969)
40

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		BIRC2	IKBKE
Description		baculoviral IAP repeat containing 2	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane Serine/threonine Protein Kinase Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Response To Bleomycin Regulation Of Reactive Oxygen Species Metabolic Process	Activation Of Innate Immune Response Response To Stress Immune Response DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Positive Regulation Of Type I Interferon Production Response To Cytokine Response To Type I Interferon Response To Interferon-beta Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly MRNA Stabilization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	SUMOylation of immune response proteins TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Fostamatinib
Diseases
GWAS		Prostate cancer ( 23535732)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		80 interacting genes: ABHD17A BIRC5 BIRC6 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L CTBP2 DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 FTCD GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 MAP3K5 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TNF TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		329	9641
HPRD ID		03419	05442
Ensembl ID		ENSG00000110330	ENSG00000263528
Uniprot IDs		Q13490	A0A075B7B4 Q14164
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR 6W74 6W7O 6W8I 7QGJ 7TRL 7TRM 8DSF 8DSO
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Cell Death Apoptotic Process Programmed Cell Death Protein Modification Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Protein Metabolic Process Regulation Of Apoptotic Process Macromolecule Catabolic Process Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Protein Catabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Transferase Activity Protein-containing Complex Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Protein Modification Process Cytoplasm Proteolysis Thioesterase Binding Proteolysis Involved In Protein Catabolic Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway CD40 Receptor Complex Nucleotide Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Modification-dependent Protein Catabolic Process	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Regulation Of Post-translational Protein Modification Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To External Biotic Stimulus Innate Immune Response-activating Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Response To Stress Response To Virus Regulation Of Apoptotic Process Regulation Of Immune Response Activation Of Immune Response Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Response To Other Organism Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Canonical NF-kappaB Signal Transduction
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